Adipose tissue, rather than serving merely as an energy store, has an essential role in regulating a wide range of metabolic functions through secretion of biological mediators known as
adipocytokines (or adipokines).
Recent studies have shown that the combination of obesity, insulin resistance and fluctuation in circulating
adipocytokines levels is associated with the pathogenesis of coronary artery disease.
Therefore, an important consideration is whether such
adipocytokines as adiponectin, a potential mediator of insulin resistance (IR), are also implicated in the pathogenesis of PCOS (3).
2] Chronic inflammation with a persistent elevation in the level of proinflammatory cytokines such as leptin, adiponectin, tumor necrosis factor-[alpha] (TNF), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1], and other
adipocytokines produced by adipocytes are shown to be associated with metabolic complications such as dyslipidaemia and are elevated in many dermatological diseases associated with chronic inflammation.
Evaluation of weight loss and
adipocytokines levels after two hypocaloric diets with different macronutrient distribution in obese subjects with rs9939609 gene variant.
Ibanez L, de Zegher F Ethinyl estradiol-drospirenone, flutamide-metformin or both for adolescents and women with hyperinsulinemic hyperandrogenism: opposite effects on
adipocytokines and body adiposity.
Chronic ethanol-induced insulin resistance is associated with macrophage infiltration into adipose tissue and altered expression of
adipocytokines.
Obesity is characterized by changes in
adipocytokines, activation of low-grade inflammation and increased production of reactive oxygen species, leading to metabolic disorders, insulin resistance (IR), and CVD (5,6).
2011) The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers,
adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus.
In addition to its function in energy storage, fat tissue also secretes many
adipocytokines such as interleukin-6, tumor necrosis factor-a, and leptin [30] that may have a catabolic effect on muscle, thus decreasing muscle mass and strength.
It has been shown that white adipose tissue is a source of specific
adipocytokines (e.
Molecular mechanism of metabolic syndrome X; contrubition
adipocytokines adipocyte devired bioactive subtances.
