adipocytokine

Adipokine

A generic term for cytokines and other modulating proteins which are secreted by adipocytes. Some—e.g., IL-6—are pro-inflammatory,  whilst others—e.g., adiponectin—have anti-inflammatory or insulin-sensitising properties. Adipokine dysregulation appears to play a central role in adiposity, metabolic syndrome, and the co-morbidities of obesity including cardiovascular disease.

adipocytokine

, adipokine (ad″ĭ-pō-sīt′ŏ-kīn″) (ad′ĭ-pŏ-kīn″) [ adipo- + cytokine]
A molecule secreted by fat cells that affects the physiology of cells in other parts of the body. Some of these molecules influence appetite, the storage of fat in the body, and systemic inflammation.
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References in periodicals archive ?
Visceral adipose tissue-specific serpin (vaspin) is a newly discovered adipocytokine secreted mainly by visceral adipose tissue that has insulin-sensitizing effects (5).
Libby, "Adiponectin: a key adipocytokine in metabolic syndrome," Clinical Science, vol.
Adiponectin (also termed acrp 30, adipoQ, APM-1, GBP28) is an adipocytokine that is generally and abundantly expressed in adipose tissue and directly sensitizes the cells to insulin.
Markers of endothelial injury and plasma adipocytokine in antiretroviral-naive HIV patients.
Thus, the data obtained so far suggest that adiponectin is an important insulin-sensitizing adipocytokine. Furthermore, it appears that various factors might increase or decrease insulin sensitivity at least partly by up- or down-regulating adiponectin.
A person's body weight, fat content and overall metabolic state are pertinent modifiers for puberty and fertility.1 Metabolic stress in terms of over nutrition and under nutrition is frequently linked to reproductive disorders.2 The connection between energy balance and reproduction are linked with the discovery of adipocytokine however, our understanding of the neurobiological basis for this phenomenon is still incomplete.
It is a pleiotropic adipocytokine which regulates the ingestion of foods, energy consumption, immunity, inflammation, hematopoiesis, cell differentiation, and proliferation [6, 7].
Wolzt, "The release of the adipocytokine visfatin is regulated by glucose and insulin," Diabetologia, vol.
This adipocytokine (leptin) together with TSH is involved in causing abnormalities in thyroid function tests via insulin-like growth factor 1 (IGF-1)11.
Nevertheless, the circulating levels of adiponectin, which is the most abundant adipocytokine, are reduced in conditions such as obesity, type 2 diabetes, and coronary heart disease (CHD) [26-28].
Kauppi et al., "Predictive value of pretretment adipocytokine levels for remission rates in early RA treated with DMARDS and infliximab," Basic & Clinical Pharmacology & Toxicology, vol.
Resistin, an adipocytokine, was initially discovered in a research conducted on obese rodents to probe the missing link between obesity, diabetes mellitus and insulin resistance.