To the best of our knowledge, this is the first study to investigate the effects of MESNA during otologic surgery, which enables cleavage of disulfate bonds and therefore, allows easy and safe dissection, particularly in cholesteatoma and adhesive otitis
media, on the facial nerve in the parotid region by physiological and histopathological methods.
Furthermore, SOM can disrupt middle ear structures and cause permanent sequelae, including tympanic membrane perforation, chronic suppurative otitis media, tympanosclerosis, adhesive otitis
media, middle ear bone necrosis, retraction pocket, cholesteatoma, and sensorineural hearing loss.
Bayazit et al similarly found that the dehiscence rate was higher in patients with cholesteatoma, followed by adhesive otitis
media, chronic otitis media, and tympanosclerosis.
 It is one of the most common health problems seen in children, leading cause of healthcare visits worldwide, and when inadequately treated or left untreated, it may lead to sequelae and complications like adhesive otitis
media, retraction pocket and impairment in development of speech and language.
A pneumococcal infection may cause a range of serious infectious diseases including pneumonia, meningitis, and adhesive otitis
media and they can be transmitted through respiratory droplets that come out of the nose or mouth.
 reported that MESNA was successful in atelectatic ears and adhesive otitis
media because it made the operation easier and safer by allowing elevation of the tympanic membrane through its mechanical and chemical actions.
The major advantage of cartilage is its stiffness and bradytrophic metabolism, which make it particularly suitable for difficult conditions, such as subtotal perforations, adhesive otitis
, and revision cases, (8) although there have been concerns that these may affect adversely acoustic transfer and the hearing.
Reversibility of chronic adhesive otitis
media with polyethylene tube, middle ear air-vent, kodachrome time lapse study.
(13-18) Atelectasis and adhesive otitis
media usually coexist with OME, leaving a collapsed middle ear; warranting specific surgeries like tympanoplasty.
There was no cholesteatoma noted, but the ear's appearance was similar to that of chronic adhesive otitis