The surface physicochemical characteristics are the main factors related to biofilm formation and expression of microorganism virulence factors such as production of exo-polymeric capsule and fimbriae and synthesis of adhesin
(GILBERT et al., 2003).
However, some adhesins
(sfa/foc, papGIII), some toxins (hlyC, cnf1), and iroN were significantly overrepresented in pneumonia E.
coli promotes the synthesis of polysaccharide adhesins
, which are required for biofilm formation.
The diversity in frequency of pap gene among different studies can be attributed to the fact that UPEC strains can utilize a variety of adhesins
to bind to the urinary epithelial cells, and start the infection.
Alteration of the pilin adhesin
of Pseudomonas aeruginosa PAO results in normal pilus biogenesis but a loss of adherence to human pneumocyte cells and decreased virulence in mice.
Prakash et al., "Identification and phenotypic characterization of a second collagen adhesin
, Scm, and genome-based identification and analysis of 13 other predicted MSCRAMMs, including four distinct pilus loci, in Enterococcus faecium," Microbiology, vol.
Furthermore, the positioning of the fimS invertible element changes to a more Phase-ON orientation and more type 1 pili are produced following the FimH tip adhesin
binding to mannose, suggesting that type 1 piliated UPEC cells change physiologically after attachment to the mannose receptors to maintain the adherence through a sustained commitment to type 1 pilus expression.
Li, "Characterization of adhesin
genes, staphylococcal nuclease, hemolysis, and biofilm formation among Staphylococcus aureus strains isolated from different source," Foodborne Pathogens and Diseases, vol.
The main criteria of selection were the bacterial expression of glycans, targeting for human Abs, and cellular receptors (adhesins
), as well as a possible involvement in autoimmune diseases (Abs to cellular receptors or human-mimic antigens) .
This complex is formed by the genes: i) Ehcp112, encoding a cysteine protease (50 kDa), and ii) Ehadh112, encoding an adhesin
Many other potential adhesins
, previously described as upregulated genes in yeast cells derived from models of infection, have been uncovered by a comparative transcriptome analysis of annotated ESTs during in vitro adherence assays to type I collagen and fibronectin, including C-5 sterol desaturase, cap20 protein, high-affinity copper transporter, hexokinase, and transketolase [37,39, 83].
mitis; this includes several putative adhesins
, as well as a capsule locus that may enable evasion of the host immune system as it does in S.