adhesin


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Related to adhesin: IgA protease

adhesin

(ăd-hē′sĭn, -zĭn)
n.
Any of various substances present on the surfaces of bacterial cells that facilitate binding to the cells of a host and that are used as antigens in some vaccines.

adhesin

[adhē′sin]
a bacterial product that enables bacteria to adhere to and colonize a host. Adherence is often an essential step in pathogenesis. Adhesins are attractive candidates for vaccines and/or components of accellular vaccines such as those for pertussis.

Adhesin

Any of a number of bacterial virulence factors—e.g., pili in Pseudomonas aeruginosa, lipotechoic acid in group A streptococci—which jut from the surface of the bacteria and bind to glycoprotein or glycolipid receptors on host epithelial cells, facilitating bacterial adherence, a critical step in bacterial infections. Adhesins are useful targets for experimental vaccines, which reduce colonisation by uropathogenic E coli. Adhesins explains the pulmonary morbidity due to P aeruginosa seen in intubated ITU/ICU patients, and UTIs caused by E coli are mediated by MS and MR adhesins, which may be inhibited by fruit juices.

adhesin

a microbial surface component, for example FIMBRIA or PILUS, that mediates ADHESION of a microorganism to a cell or substratum. Adhesion to specific host RECEPTORS is often a preliminary stage in pathogenesis (see PATHOGEN). Adhesins are important VIRULENCE factors.
References in periodicals archive ?
In staphylococci, the main molecule responsible for intercellular adhesion is a polysaccharide intercellular adhesin (PIA), also known as a poly-N-acetylglucosamine (PNAG [9]).
Miyata, "Isolation and characterization of P1 adhesin, a leg protein of the gliding bacterium Mycoplasma pneumoniae," Journal of Bacteriology, vol.
pylori to the gastric epithelial cell surface through formation of membrane attachment pedestals requires bacterial adhesins to recognise and specifically bind to host receptors expressed on the cell surface.
1998) Minimum chemi cal requirements for adhesin activity of the acidstable part of Candida albicans cell wall phosphomannoprotein complex.
Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin.
pneumoniae was accompanied by significant increases in capsule-specific IgG, as well as by small but significant increases in antibodies to both pneumolysin and pneumococcal surface adhesin A (PsaA), but not to pneumococcal surface protein A (PspA), with higher levels of anti-capsular antibodies at the outset being associated with a reduction in carriage.
Although it seems unlikely that Microciona would encounter the HJV virus in its natural surrounding, we propose that this model typifies cross-species binding (as demonstrated by a non-self adhesin unrelated to the known self-binding epitapes), and it may provide the sponge with a means of immobilizing symbionts or other forms that are required for nutrition or far disposal by macrophages.
meningitidis adhesin A variant had an insertion sequence that disrupted this gene, as described for ET-15 meningococci (10).
Directed mutagenesis of adhesin genes in several oral pathogens will be used to create a library of knockout strains.
faecium Acm collagen-binding protein (adhesin); efaA, cell wall adhesin expressed in patient serum (endocarditis-specific antigen A) for both species; eep (enhanced expression of pheromone), membrane protein of E.