adhesin


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Related to adhesin: IgA protease

adhesin

(ăd-hē′sĭn, -zĭn)
n.
Any of various substances present on the surfaces of bacterial cells that facilitate binding to the cells of a host and that are used as antigens in some vaccines.

Adhesin

Any of a number of bacterial virulence factors—e.g., pili in Pseudomonas aeruginosa, lipotechoic acid in group A streptococci—which jut from the surface of the bacteria and bind to glycoprotein or glycolipid receptors on host epithelial cells, facilitating bacterial adherence, a critical step in bacterial infections. Adhesins are useful targets for experimental vaccines, which reduce colonisation by uropathogenic E coli. Adhesins explains the pulmonary morbidity due to P aeruginosa seen in intubated ITU/ICU patients, and UTIs caused by E coli are mediated by MS and MR adhesins, which may be inhibited by fruit juices.

adhesin

a microbial surface component, for example FIMBRIA or PILUS, that mediates ADHESION of a microorganism to a cell or substratum. Adhesion to specific host RECEPTORS is often a preliminary stage in pathogenesis (see PATHOGEN). Adhesins are important VIRULENCE factors.
References in periodicals archive ?
In the experimental mouse model, the designer adhesin protein spontaneously inserts into the plasma membrane of the stem cells with no cytotoxity, and then directs the modified cells to the heart after transplant.
Characterization of the N-acetylglucosaminyltransferase activity involved in the biosynthesis of the Staphylococcus epidermidis polysaccharide intercellular adhesin. J.
According to previous research, virulence factors include genes encoding iron acquisition systems (iron, iuc), adhesins (fim, afal, sfa, iha), toxins (cnf1, hlyA, set, astA, usp), and biofilms (pgaABCD).
(41-44) Our observations suggest the potential of type 1 fimbrial adhesin as promising candidates for the development of new therapeutic strategies to prevent complications related to UPEC colonization.
Contrepois adhesin is the surface of some macromolecular structure components in mostly bacteria, mainly fimbriae adhesin and afimbrial adhesion, and basis of biological engraftment which is the precondition of bacteria infection usually.
Bacterial attachment is an initial and a critical step for the establishment of infection that involves bacterial adhesins and host receptors.
Schapendonk et al., "SgrA, a nidogen-binding LPXTG surface adhesin implicated in biofilm formation, and EcbA, a collagen binding MSCRAMM, are two novel adhesins of hospital-acquired Enterococcus faecium," Infection and Immunity, vol.
Furthermore, the positioning of the fimS invertible element changes to a more Phase-ON orientation and more type 1 pili are produced following the FimH tip adhesin binding to mannose, suggesting that type 1 piliated UPEC cells change physiologically after attachment to the mannose receptors to maintain the adherence through a sustained commitment to type 1 pilus expression.
The blood group antigen binding adhesin (babA), a 78 KDa outer membrane protein encoded by the babA2 gene, binds to Lewis b antigens and ABO antigen [18,19].
Li, "Characterization of adhesin genes, staphylococcal nuclease, hemolysis, and biofilm formation among Staphylococcus aureus strains isolated from different source," Foodborne Pathogens and Diseases, vol.
Boneca et al., "The LacdiNAc-specific adhesin laba mediates adhesion of Helicobacter pylori to human gastric mucosa," The Journal of Infectious Diseases, vol.
Servicio de telecomunicaciones para el Ayuntamiento de Fuenlabrada y por adhesin de sus Organismos Autnomos (Patronato Municipal de Deportes, Patronato Municipal de Cultura, Centro de Iniciativas para la Formacin y el Empleo, Instituto Municipal de Limpieza y Oficina Tributaria del Ayuntamiento de Fuenlabrada).