adenylate cyclase


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Related to adenylate cyclase: cyclic AMP, Phospholipase C, Protein kinase A

adenylate cyclase

 [ah-den´ĭ-lāt si´clās]
an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP) and inorganic pyrophosphate (PPi ). It is activated by the attachment of a hormone or neurotransmitter to a specific membrane-bound receptor.

a·den·y·late cy·clase

an enzyme acting on ATP to form 3',5'-cyclic AMP plus pyrophosphate, a crucial step in the regulation and formation of second messengers.
Synonym(s): 3', 5'-cyclic AMP synthetase

adenylate cyclase

(ə-dĕn′əl-ĭt, ăd′n-ĭl′ĭt) also

adenyl cyclase

(ə-dĕn′əl, ăd′n-ĭl)
n.
An enzyme that catalyzes the formation of cyclic AMP from ATP and plays a key role in signal transduction.

adenylate cyclase

an enzyme that initiates the conversion of adenosine triphosphate to cyclic adenosine monophosphate, a mediator of many physiological activities.

Adenylate Cyclase

An enzyme that catalyses ATP to form 3’,5’-cyclic AMP and inorganic pyrophosphate. G proteins dissociate into GTP-bound alpha subunits—activating adenylyl cyclase, retinal phosphodiesterase, phospholipase C, and ion channels—and a complex of beta and gamma subunits, selectively activating certain forms of adenylate cyclase following interaction with the cell receptors. Adenylate cyclase is intimately linked to the receptor-G protein machinery on the cytoplasmic face of cell membrane, which generates the second messenger, cAMP, when stimulated by an extracellular message in the form of receptor binding of a hormone or other ligand, light, or odours. Adenylate cyclase is the prototypic second messenger generator, and is regulated by one or the other arm of the phospholipase C pathway. It is further regulated by cyclic changes in cAMP and internal Ca2+ levels.

a·den·y·late cy·clase

(ă-den'i-lāt sī'klās)
An enzyme acting on ATP to form 3',5'-cyclic AMP plus pyrophosphate. A crucial step in the regulation and formation of second messengers.
Synonym(s): 3', 5'-cyclic AMP synthetase.

adenylate cyclase

The enzyme that converts ADENOSINE TRIPHOSPHATE (ATP) to cyclic AMP.

adenylate

a salt, anion or ester of adenylic acid.

adenylate cyclase
an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP) and inorganic pyrophosphate. It is activated by the attachment of a hormone or neurotransmitter to a specific membrane-bound receptor.
adenylate kinase
enzyme catalyzing the conversion of two moles of ADP to ATP and AMP, thereby equilibrating ADP with ATP and AMP. Controls the adenylate energy charge of a cell, particularly muscle cells. Called also myokinase.
References in periodicals archive ?
subunits were also demonstrated to be involved in activation or inhibition of adenylate cyclase (see review ref.
Effects of sub-chronic in vivo chlorpyrifos exposure on muscarinic receptors and adenylate cyclase of rat striatum.
The activity of intracellular adenylate cyclase is usually estimated by measuring the accumulation of cAMP in the presence of inhibitors of phosphodiesterases [22].
On the other hand, the peptide ubiquitin, an adenylate cyclase activator |20~ which is usually present in histone preparations, did not show any interfering activity in our IRMAs, thus serving as a negative control.
Furthermore, adenylate cyclase activity stimulated by cesium fluoride was abnormally low among 10 alcoholics in the sample who had abstained from alcohol for one to four years.
With the exception of the adenylate cyclase activator forskolin and the phorbol ester TPA, all of the other neuropharmacological agents used to test GPCRs and the AC/cAMP pathway had no effect on metamorphosis (Figs.
We further demonstrated that G proteins, adenylate cyclase and protein kinase A were required for the increased neuronal excitability.
The A subunit of cholera toxin activates adenylate cyclase, causing increased [Cl.
Lithium acts by altering intraneuronal metabolism of catecholamines, inhibiting noradrenaline-sensitive adenylate cyclase, reducing synaptic transmission, and increasing neuronal excitability with modification of the central nervous system (CNS) amine concentrations.
6] Some are capable of stimulating adenylate cyclase, resulting in cyclic adenosine monophosphate (cAMP) generation and autonomous thyroid hormone production.
Previous research had shown that G(i)is one of two G proteins that serve as a link between a cellular enzyme called adenylate cyclase and hormone receptors found on the cell surface: In a complex regulatory process, G(s) stimulates and G(i) inhibits adenylate cyclase's response to hormones.
Such effector function is composed of adenylate cyclase stimulation resulting in the production of cyclic AMP; (cAMP), phospholipase C and A2 stimulation generating inositol-1,4,5- trisphosphate (IP3), cGMP phosphodiesterase activity, or the stimulation of calcium [Ca2+] fluxes in vivo--mediated by release of Ca2+ from intracellular stores.