It is known that all these receptors (alpha-2) couple to the inhibitory heterotrimeric GTP-binding protein (Gi) and inhibit adenyl
In vitro studies show that opioids inhibit activation of adenyl
cyclase (6) and also stimulate the formation of cGMP (7).
The pharmacologic effects of a beta 2-adrenoceptor agonist drugs stimulate adenyl
cyclase to cyclic 3'5' adenosine monophosphate (cyclic AMP).
Cholera--The cholera enterotoxin produced by Vibrio cholerae stimulates adenyl
cyclase, an intestinal enzyme that causes secretion of large volumes of watery fluid (as much as one L/hour).
Numerous enzymes, such as adenyl
cyclase and protein kinase A involved in energy regulation, are upregulated by DHA.
Somatostatin receptors, an expanding gene family: cloning and functional characterisation of human SSTR3, a protein coupled to adenyl
Epinephrine, a primary messenger acts by activating the adenyl
cyclase system which catalyzes the synthesis of cyclic AMP from ATP.
Epinephrine activates the enzyme adenyl
cyclase, which subsequently activates the phosphorylase enzyme system which, ultimately, converts glucose to glucose-6-phosphate (G6P).
ADP-induced platelet activation relies on the G protein response and the eicosanoid synthesis pathway to suppress adenyl
cyclase activity and induce calcium mobilization to the platelet cytosol.
The mutation leads to a loss of guanosine triphosphatase activity and thus to adenyl
cyclase overactivity and subsequent overproduction of cyclic adenosine monophosphate (cAMP).
cyclase activity as a trait marker of alcohol dependence.