Edelman, "Effects of [Ca.sup.++] and prostaglandin [E.sub.1] on vasopressin activation of renal adenyl
cyclase," The Journal of Clinical Investigation, vol.
Forskolin, one of these diterpenes, directly acts on adenyl
cyclase and leads to increased intracellular levels of the second messenger cAMP.
Group II (mGlu2 and 3) and Group III (mGlu4, 6, 7, and 8) receptors are negatively coupled to adenyl
cyclase and inhibit cAMP formation.
Emerging evidence suggests that [M.sub.2] muscarinic receptors, via inhibition of adenyl
cyclase, cause smooth muscle contraction indirectly by inhibiting sympathetically (beta-adrenoceptor)-mediated relaxation .
Additionally sustained [Ca.sup.2+] channel blockade results in modulation in the adenyl
cyclase effectors system activated by [mu],-opioid receptor activation, leading to the suppression of opioid tolerance and restoration of super-sensitivity (Hurle et al.
The pathogenesis of FD involves somatic activating mutation of the gene encoding the alpha subunit of the stimulatory G protein in the bone marrow cells, resulting in locally increased stimulatory activity of adenyl
cyclase and cAMP.
Bromocriptine is an ergot alkaloid derivative, structurally related to dopamine (1) Bromocriptine is a dopamine receptor agonist that inhibits prolactin secretion (2, 3, 4, 5) through the inhibition of adenyl
cyclase activity (1) and is commonly used in the treatment of hyperprolactinemia, Parkinsonism and acromegaly (6,7).
Clopidogrel may block ADP-induced platelet aggregation via G protein activation and inhibition of adenyl
cyclase or it may be totally independent from these factors.
It is known that all these receptors (alpha-2) couple to the inhibitory heterotrimeric GTP-binding protein (Gi) and inhibit adenyl
In vitro studies show that opioids inhibit activation of adenyl
cyclase (6) and also stimulate the formation of cGMP (7).
The pharmacologic effects of a beta 2-adrenoceptor agonist drugs stimulate adenyl
cyclase to cyclic 3'5' adenosine monophosphate (cyclic AMP).