adenyl


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ad·e·nyl

(ad'e-nil),
The radical or ion of adenine; often used for adenylyl, as in adenylosuccinic acid.

ad·e·nyl

(ad'ĕ-nil)
The radical or ion of adenine.

adenyl

(ad′ĕ-nil) [ aden- + -yl]
The radical C5H4N5; present in adenine.

adenyl cyclase

An enzyme that catalyzes the production of cyclic AMP (adenosine 3′,5′-cyclic monophosphate) from ATP (adenosine triphosphate). It is present on most cell surfaces.
References in periodicals archive ?
Edelman, "Effects of [Ca.sup.++] and prostaglandin [E.sub.1] on vasopressin activation of renal adenyl cyclase," The Journal of Clinical Investigation, vol.
Forskolin, one of these diterpenes, directly acts on adenyl cyclase and leads to increased intracellular levels of the second messenger cAMP.
Group II (mGlu2 and 3) and Group III (mGlu4, 6, 7, and 8) receptors are negatively coupled to adenyl cyclase and inhibit cAMP formation.
Emerging evidence suggests that [M.sub.2] muscarinic receptors, via inhibition of adenyl cyclase, cause smooth muscle contraction indirectly by inhibiting sympathetically (beta-adrenoceptor)-mediated relaxation [14].
Additionally sustained [Ca.sup.2+] channel blockade results in modulation in the adenyl cyclase effectors system activated by [mu],-opioid receptor activation, leading to the suppression of opioid tolerance and restoration of super-sensitivity (Hurle et al.
The pathogenesis of FD involves somatic activating mutation of the gene encoding the alpha subunit of the stimulatory G protein in the bone marrow cells, resulting in locally increased stimulatory activity of adenyl cyclase and cAMP.
Bromocriptine is an ergot alkaloid derivative, structurally related to dopamine (1) Bromocriptine is a dopamine receptor agonist that inhibits prolactin secretion (2, 3, 4, 5) through the inhibition of adenyl cyclase activity (1) and is commonly used in the treatment of hyperprolactinemia, Parkinsonism and acromegaly (6,7).
Clopidogrel may block ADP-induced platelet aggregation via G protein activation and inhibition of adenyl cyclase or it may be totally independent from these factors.
It is known that all these receptors (alpha-2) couple to the inhibitory heterotrimeric GTP-binding protein (Gi) and inhibit adenyl cyclase (22).
In vitro studies show that opioids inhibit activation of adenyl cyclase (6) and also stimulate the formation of cGMP (7).
The pharmacologic effects of a beta 2-adrenoceptor agonist drugs stimulate adenyl cyclase to cyclic 3'5' adenosine monophosphate (cyclic AMP).

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