adenosine triphosphate


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adenosine

 [ah-den´o-sēn]
1. a nucleoside composed of the pentose sugar d-ribose and adenine. It is a structural subunit of ribonucleic acid (RNA). Adenosine nucleotides are involved in the energy metabolism of all cells. Adenosine can be linked to a chain of one, two, or three phosphate groups to form adenosine monophosphate (AMP), adenosine diphosphate (ADP), or adenosine triphosphate (ATP). The bond between the phosphate groups in ADP or the two bonds between phosphate groups in ATP are called high-energy bonds, because hydrolysis of a high-energy bond provides a large amount of free energy that can be used to drive other processes that would not otherwise occur. The energy that is derived from the breakdown of carbohydrates, fats, or proteins is used to synthesize ATP. The energy stored in ATP is then used directly or indirectly to drive all other cellular processes that require energy, of which there are four major types: (1) the transport of molecules and ions across cell membranes against concentration gradients, which maintains the internal environment of the cell and produces the membrane potential for the conduction of nerve impulses; (2) the contraction of muscle fibers and other fibers producing the motion of cells; (3) the synthesis of chemical compounds; (4) the synthesis of other high-energy compounds.
Adenosine.
2. a preparation of adenosine, which acts as a cardiac depressant of automaticity in the sinus node and conduction in the atrioventricular node and as a vasodilator. It is used as an antiarrhythmic and is also used to cause coronary vasodilation during myocardial perfusion imaging in patients who cannot exercise adequately to perform an exercise stress test, administered intravenously.
cyclic adenosine monophosphate a cyclic nucleotide, adenosine 3′,5′-cyclic monophosphate, involved in the action of many hormones, including catecholamines, ACTH, and vasopressin. The hormone binds to a specific receptor on the cell membrane of target cells. This activates an enzyme, adenylate cyclase, which produces cyclic AMP from ATP. Cyclic AMP acts as a second messenger activating other enzymes within the cell. Abbreviated 3′,5′-AMP, cAMP, and cyclic AMP.
adenosine diphosphate (ADP) a nucleotide, adenosine 5′-pyrophosphate, produced by the hydrolysis of adenosine triphosphate (ATP). It is then converted back to ATP by the metabolic processes oxidative phosphorylation, glycolysis, and the tricarboxylic acid cycle.
adenosine monophosphate (AMP) a nucleotide, adenosine 5′-phosphate, involved in energy metabolism and nucleotide synthesis. Called also adenylic acid.
adenosine triphosphatase (ATPase) a term used to refer to the enzymatic activity of certain intercellular processes that split ATP to form ADP and inorganic phosphate, when the energy released is not used for the synthesis of chemical compounds. Examples are the splitting of ATP in muscle contraction and the transport of ions across cell membranes.
adenosine triphosphate (ATP) a nucleotide, adenosine 5′-triphosphate, occurring in all cells, where it stores energy in the form of high-energy phosphate bonds. Free energy is supplied to drive metabolic reactions, to transport molecules against concentration gradients (active transport), and to produce mechanical motion (contraction of myofibrils and microtubules), when ATP is hydrolyzed to ADP and inorganic phosphate or to AMP and inorganic pyrophosphate. ATP is also used to produce high-energy phosphorylated intermediary metabolites, such as glucose 6-phosphate.

a·den·o·sine 5'-tri·phos·phate (ATP),

(ă-den'ō-sēn trī-fos'fāt),
Adenosine with triphosphoric acid esterified at its 5' position; immediate precursor of adenine nucleotides in RNA; the primary energy currency of a cell.

adenosine triphosphate

n.
ATP.

adenosine triphosphate (ATP)

a compound consisting of the nucleotide adenosine (A) attached through its ribose group to three phosphoric acid molecules (P). Hydrolysis of ATP to adenosine diphosphate (D) releases energy. By coupling a less favorable reaction in the cell with this hydrolysis, the less favorable reaction may proceed, allowing one to think of ATP as the cellular energy currency, especially in muscle.
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Adenosine triphosphate in metabolism

adenosine triphosphate

An adenosine with 3 high-energy phosphates, which is required for RNA synthesis and present in all living cells; ATP is a key energy source which drives many metabolic processes, including those involving motor proteins, movement of molecules against concentration gradients and the synthesis of proteins, nucleic acids and other molecules.

adenosine triphosphate (ATP)

A compound found in cells, consisting of the NUCLEOSIDE adenosine attached to three molecules of phosphoric acid. Adenosine triphosphate is the main energy-releasing entity of the cell. While it is being formed from adenosine diphosphate (ADP), ATP accepts energy from the breakdown of fuel molecules. During its breakdown to ADP or AMP it donates the energy to cell functions. As the energy source for the entire body, ATP is constantly being formed and broken down. At rest, a human consumes about 40 Kg of ATP per day. During strenuous exercise the rate of ATP cycling may reach half a Kg per minute.

adenosine triphosphate

see ATP.

adenosine triphosphate

; ATP; adenosine diphosphate; ADP intracellular biochemicals; ATP releases energy (to fuel intracellular reactions) when hydrolysed by enzymic action into ADP; ADP is later reconverted to ATP by energy-dependent enzymic reactions

adenosine triphosphate (·deˑ·n·sēn trī·fsˑ·fāt),

n the compound that is hydrolyzed to produce the energy necessary for metabolic processes. Also called
ATP.

a·den·o·sine 5'-tri·phos·phate

(ATP) (ă-denŏ-sēn trī-fosfāt)
Adenosine with triphosphoric acid esterified at its 5' position; immediate precursor of adenine nucleotides in RNA; the promary energeny of a cell.
References in periodicals archive ?
Duska) is a specialty pharmaceutical company that develops new cardiovascular medicines based upon the emerging new pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO).
Duska) is a specialty pharmaceutical company that develops new cardiovascular and pulmonary medicines based upon the emerging new pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO).
It forms the core of adenosine triphosphate, or ATP, the energy-storage molecule that powers most of the biochemical reactions inside cells.
Eliezer Rapaport, the licensor of the Company's potential adenosine triphosphate ("ATP") drug, has requested arbitration by the American Arbitration Association of his claim that the Company has breached its May 20, 1991 license agreement by failing to devote reasonable efforts in preparing and filing a New Drug Application within three years of FDA approval of its Investigational New Drug application for the use of ATP in the treatment of at least one type of human cancer.
AMEX: MRE) today announced positive Phase II clinical results for its anti-cancer drug, adenosine triphosphate (ATP), in patients with non-small cell lung cancer.
After individuals complete a stressful laboratory test, their blood platelets secrete much more of a substance called adenosine triphosphate (ATP).
Foker's experiments showed that ribose dramatically decreased recovery time of adenosine triphosphate (ATP) in cardiac tissue following cardiac surgery.
These locomotive enzymes burn a cellular fuel called adenosine triphosphate (ATP).
AMEX: MRE) today announced it has completed a Phase I trial of adenosine triphosphate (ATP) in cancer patients.
That ancient RNA would have needed the ability to perform the tasks of many modern proteins, such as binding to an energy-transfer molecule called adenosine triphosphate (ATP).
Myosin obtains the chemical energy needed to fuel this shortening by breaking phosphate off adenosine triphosphate (ATP) molecules.
Medco") (AMEX: MRE) today announced that it is initiating Phase I clinical trials of adenosine triphosphate (ATP) for the treatment of advanced metastatic cancer and cancer-related cachexia (general ill health and malnutrition).

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