adenosine diphosphate

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Related to adenosine diphosphate: adenosine monophosphate


1. a nucleoside composed of the pentose sugar d-ribose and adenine. It is a structural subunit of ribonucleic acid (RNA). Adenosine nucleotides are involved in the energy metabolism of all cells. Adenosine can be linked to a chain of one, two, or three phosphate groups to form adenosine monophosphate (AMP), adenosine diphosphate (ADP), or adenosine triphosphate (ATP). The bond between the phosphate groups in ADP or the two bonds between phosphate groups in ATP are called high-energy bonds, because hydrolysis of a high-energy bond provides a large amount of free energy that can be used to drive other processes that would not otherwise occur. The energy that is derived from the breakdown of carbohydrates, fats, or proteins is used to synthesize ATP. The energy stored in ATP is then used directly or indirectly to drive all other cellular processes that require energy, of which there are four major types: (1) the transport of molecules and ions across cell membranes against concentration gradients, which maintains the internal environment of the cell and produces the membrane potential for the conduction of nerve impulses; (2) the contraction of muscle fibers and other fibers producing the motion of cells; (3) the synthesis of chemical compounds; (4) the synthesis of other high-energy compounds.
2. a preparation of adenosine, which acts as a cardiac depressant of automaticity in the sinus node and conduction in the atrioventricular node and as a vasodilator. It is used as an antiarrhythmic and is also used to cause coronary vasodilation during myocardial perfusion imaging in patients who cannot exercise adequately to perform an exercise stress test, administered intravenously.
cyclic adenosine monophosphate a cyclic nucleotide, adenosine 3′,5′-cyclic monophosphate, involved in the action of many hormones, including catecholamines, ACTH, and vasopressin. The hormone binds to a specific receptor on the cell membrane of target cells. This activates an enzyme, adenylate cyclase, which produces cyclic AMP from ATP. Cyclic AMP acts as a second messenger activating other enzymes within the cell. Abbreviated 3′,5′-AMP, cAMP, and cyclic AMP.
adenosine diphosphate (ADP) a nucleotide, adenosine 5′-pyrophosphate, produced by the hydrolysis of adenosine triphosphate (ATP). It is then converted back to ATP by the metabolic processes oxidative phosphorylation, glycolysis, and the tricarboxylic acid cycle.
adenosine monophosphate (AMP) a nucleotide, adenosine 5′-phosphate, involved in energy metabolism and nucleotide synthesis. Called also adenylic acid.
adenosine triphosphatase (ATPase) a term used to refer to the enzymatic activity of certain intercellular processes that split ATP to form ADP and inorganic phosphate, when the energy released is not used for the synthesis of chemical compounds. Examples are the splitting of ATP in muscle contraction and the transport of ions across cell membranes.
adenosine triphosphate (ATP) a nucleotide, adenosine 5′-triphosphate, occurring in all cells, where it stores energy in the form of high-energy phosphate bonds. Free energy is supplied to drive metabolic reactions, to transport molecules against concentration gradients (active transport), and to produce mechanical motion (contraction of myofibrils and microtubules), when ATP is hydrolyzed to ADP and inorganic phosphate or to AMP and inorganic pyrophosphate. ATP is also used to produce high-energy phosphorylated intermediary metabolites, such as glucose 6-phosphate.

a·den·o·sine 5'-di·phos·phate (ADP),

(ă-den'ō-sēn dī-fos'fāt),
A condensation product of adenosine with pyrophosphoric acid, formed from ATP by the hydrolysis of the terminal phosphoryl group of the latter compound.

adenosine diphosphate


adenosine diphosphate (ADP)

a product of the hydrolysis of adenosine triphosphate.

adenosine diphosphate

An adenosine with 2 high-energy phosphates, which results from the hydrolysis of ATP, that occurs in many metabolic processes. ADP is converted back to ATP by oxidative phosphorylation.

adenosine diphosphate

see ADP.

adenosine diphosphate (·deˑ·n·sēn dī·fsˑ·fāt),

n the compound produced when adenosine triphosphate (ATP) is hydrolyzed and energy is released. It is also used in the synthesis of ATP. Also called
References in periodicals archive ?
Data were recorded as inhibition of platelet aggregation (IPA): 100–100 x ([MA[sub]ADP − MA[sub]FIBRIN]/[MA[sub]THROMBIN − MA[sub]FIBRIN]), where MA[sub]ADP is the adenosine diphosphate (ADP)-induced clot strength (measurement of clopidogrel effect), MA[sub]FIBRIN is the fibrin induced clot strength (measurement of fibrin contribution), and MA[sub]THROMBIN is the thrombin-induced clot strength (maximum clot strength).
sup][5] The cluster of differentiation 38 (CD38)/cyclic adenosine diphosphate ribose (cADPR) pathway is an important regulator of intracellular Ca [sup]2+ mobilization.
sup][13] Blocking the CD38/cADPR pathway with 8-bromo-cyclic adenosine diphosphate ribose (8-Br-cADPR), which is a specific inhibitor of cADPR, could reduce intracellular Ca [sup]2+,[10],[14],[15] reactive oxygen species (ROS),[sup][16],[17] proinflammatory cytokines,[sup][14],[15] and attenuate tissue injury such as neuroinflammation,[sup][18] cardiac ischemia/reperfusion injury [sup][19] and airway hyper-responsiveness.
sup][3],[4],[5],[6] Therefore, HPR to adenosine diphosphate (ADP) assessed by several platelet function tests is a major risk factor for the occurrence of ischemic events following PCI.

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