For patients with one 1st degree relative with
adenomatous polyps, the relative risk is 1.
Enterix has also identified and filed patent applications covering novel genomic markers that identify the development of pre-cancerous
adenomatous polyps in the colon and rectum.
Adenomatous polyps have been associated with adenocarcinoma of the colon by several lines of evidence: 1) adenomas are uncommon in areas where colon cancer is low; 2) the incidence of colonic adenomas increases with age in countries with a high or intermediate risk for colon cancer, occurring in 30 percent to 40 percent of individuals older than 60 years in the United States; and 3) the potential of
adenomatous polyps to transform into adenocarcinoma increases with the size and histologic appearance of the polyps.
All colorectal cancers develop from
adenomatous polyps that grow over years.
A third study that has not yet been published--the Prevention of Colorectal Sporadic
Adenomatous Polyps (PreSAP) trial--found similar results in high-risk patients randomized to preventive therapy with celecoxib compared with placebo.
Patients with a first degree relative with colorectal cancer or
adenomatous polyps should begin having yearly screening colonoscopies at age 40, or 10 years prior to the earliest diagnosis in the family.
24,29) It is important to remember that
adenomatous polyps (particularly advanced lesions) are the primary target of screening.
If you take people with colon cancer or
adenomatous polyps and remove the cancer or polyp, their colons are still abnormal," says Mason.
Doctors have long known that so-called
adenomatous polyps in the colon--such as the ones removed from former President Reagan during his term of office-- can become cancerous.
Exact's multi-center DeeP-C study (Multi-Target Colorectal Cancer Screening Test for the Detection of Colorectal Advanced
Adenomatous Polyps and Cancer) will generate data to support its planned PMA submission to the U.
For biomarker discovery, plasma RNA was extracted from 3 patient study: i) Colonoscopy negative individuals; ii) Advanced
adenomatous polyps (pre-cancer) - confirmed by colonoscopy; and iii) Colorectal cancer patients (stages I-III).
A family history of colon cancer or
adenomatous polyps significantly increases your chances of developing the disease, and the more family members you have with colon cancer, the higher your risk.
