adenocarcinoma in situ


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ad·e·no·car·ci·no·ma in si·'tu

a noninvasive, abnormal proliferation of glands believed to precede the appearance of invasive adenocarcinoma; reported in the endometrium, breast, large intestine, cervix, and other sites.

ad·e·no·car·ci·no·ma in si·tu

(adĕ-nō-kahr-si-nōmă in sitū)
Noninvasive, abnormal proliferation of glands believed to precede the appearance of invasive adenocarcinoma.

adenocarcinoma in situ

Abbreviation: AIS
A localized cluster of malignant appearing cells found in a gland but not yet spreading outside the basement membrane of the gland.
See also: adenocarcinoma
References in periodicals archive ?
66 Uterine corpus Endometrioid adenocarcinoma, G1 of uterine corpus (7) Our case 66 Uterine cervix Gastric type adenocarcinoma in situ of uterine cervix TC, tunnel cluster; TZ, transformation zone; LEGH, lobular endocervical glandular hyperplasia; SGM, simple gastric metaplasia; SMILE, stratified mucin-producing intraepithelial lesion.
The anatomic distribution of cervical adenocarcinoma in situ: implications for treatment.
IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expression.
A and B, Endometriosis mimicking endocervical adenocarcinoma in situ (AIS) in a cervical biopsy.
Diagnosis of lung adenocarcinoma in situ and minimally invasive adenocarcinoma from intraoperative frozen sections: an analysis of 136 cases [published online ahead of print May 12, 2016].
Adenocarcinoma in situ was more frequently interpreted as atrophic vaginitis on SurePath than on ThinPrep slides, but less frequently interpreted as NILM or reparative changes (Table 3).
As noted above, there may be rare cases of mucinous adenocarcinoma in situ or mucinous minimally invasive adenocarcinoma.
Benign endocervix (A, D), adenocarcinoma in situ (B, E), and invasive adenocarcinoma (C, F) demonstrate nuclear positivity for PAX8 (D through F) (hematoxylin-eosin, original magnification X100 [A through C]; original magnification X100 [D through F]).
Adenocarcinoma in situ and minimally invasive adenocarcinomas are of special interest because of their 100% and near 100% 5-year survival, respectively, if completely resected.
(%) 5707 (2.7) 5820 (2.7) Abbreviations: ADC, adenocarcinoma; AGC, atypical glandular cells; AIS, adenocarcinoma in situ; ASC-H, atypical squamous cells, cannot exclude high grade squamous intraepithelial lesion; ASC-US, atypical squamous cells of undetermined significance; HSIL, high-grade squamous intraepithelial lesion; LSIL, low-grade squamous intraepithelial lesion; SCC, squamous cell carcinoma.
Adenocarcinoma in situ is characterized by a set of well-established architectural and cytologic features (Figure 1, A and B).
Lung adenocarcinoma in situ. Atypical epithelial cells line thickened alveolar walls in a lepidic pattern and show cellular crowding, nuclear pleomorphism, and hyperchromasia (hematoxylineosin, original magnification X10).