adduct


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adduct

 [ah-dukt´]
to draw toward an axis or median line.

ad·duct

(a'dŭkt), Do not confuse this word with abduct.
1. To draw toward the median plane.
2. An addition product, or complex, or one part of the same.
[L. ad-duco, pp. -ductus, to bring toward]

adduct

(ə-dŭkt′, ă-dŭkt′)
tr.v. ad·ducted, ad·ducting, ad·ducts Physiology
To draw inward toward the median axis of the body or toward an adjacent part or limb.
n. Chemistry
A chemical compound that forms from the addition of two or more substances.

ad·duc′tion n.
ad·duc′tive adj.

Adduct

noun
Biochemistry A term for the covalent complex formed when a chemical binds a biomolecule, such as DNA or a protein.
Chemistry A compound produced by mixing 2 or more chemicals.
Molecular biology (1) A molecular complex consisting of a chemical—e.g., environmental toxins like polyaromatic hydrocarbons—bound to a biomolecule—e.g., DNA, protein, especially those that attach after exposure to air pollution, cigarette smoke, and other environmental contaminants. 
(2) A molecule resulting from a reaction between molecules with major parallel axes—i.e., molecules with overlapping effects.
Molecular oncology A chemical bond between any substance and DNA, which may upregulate a gene; DNA-carcinogen adducts can drive a cell’s molecular machinery towards malignancy.
verb To move toward the body.

ad·duct

(ă-dŭkt')
To draw toward the midline of the body or segment.
[L. ad-duco, pp. -ductus, to bring toward]

adduct 

To turn towards the midline.

ad·duct

(ă-dŭkt')
1. To draw toward the median plane.
2. An addition product, or complex, or one part of the same.
[L. ad-duco, pp. -ductus, to bring toward]
References in periodicals archive ?
The mechanism of action of cisplatin is mediated by the interaction of cisplatin with DNA in order to for DNA adducts. The principle of action involves exerting its cytotoxicity upon cancer cells through the formation of DNA adducts that include mono-, inter, and intrastrand cisplatin DNA crosslinks that arrest the cell cycle at S, G1 or G2-M thus induces apoptosis (3).
Epoxy-amine adducts based on MCDA (Baxxodur[R] EC 210) were readily synthesized, with DGEBA-diamine adduct ratios ranging from 1:16 to 1:2.5.
Synthesis of the Thermo-Reversible Adduct and Resin Formulation
--finally, studies that did not use high-pressure liquid chromatograph (HPLC), 32P-post-labeling assay, and cytokinesis-block micronucleus (CBMN) assay for the detection of 1-OHP, DNA adduct and micronuclei frequency, respectively, were also excluded.
Investigation for DNA adducts by analysis of genomic DNA from leucocytes by gas-liquid chromatography showed the presence of epoxy-oleic acid, which was localised to the N-formyl peptide receptors (FPRs) using DNA microarrays.
Although the interactions between amino acid carboxylic group and heterocyclic nitrogen are significantly stronger than the interactions involving amino group of amino acid and heterocyclic nitrogen [20], the adduct 7-Ala was additionally optimized regarding the interaction of the alanine amino group and pyrazole nitrogen atoms (adduct 7AlaB-N, B3LYP/6-31G(d,p) level of theory; Figure S3, Supplementary Material).
The detection of acetaldehyde/ liver plasma membrane protein adduct formed in vivo by alcohol feeding.
Procedure for the synthesis of Baylis-Hillman adduct (6)
[M.sub.1]dG is the major DNA adduct arising from malondialdehyde, a genotoxic by-product of lipid peroxidation of polyunsaturated fatty acids with a high number of double bonds that also can be formed during food preparation (Jeong and Swenberg 2005).
The utilization of covalent inhibitors that reversibly form an adduct with the protein cysteine is attractive as they may provide the pharmacodynamic and selectivity benefit with less propensity to form long-lived protein adducts.