Studies of the Milan hypertensive (MHS) rat and of humans with essential hypertension suggest that genetic alterations in adducin may contribute to hypertension (1).
Adducin is a heterodimeric cytoskeleton protein that consists of [alpha]-, [beta]- and [gamma]- similar subunits.
Hypertension-associated point mutations in the adducin alpha and beta subunits affect actin cytoskeleton and ion transport.
Evidence for an interaction between adducin and Na+-K+-ATPase: Relation to genetic hypertension.
Adducin polymorphism detection and impact on hypertension and related disorders.
Results for gene expression were 2558) genes expressed in all 10 samples, 2629 genes expressed in all 5 samples from male donors, 3343 expressed in all 5 samples from female donors, and 4013 unique genes (from a total of 8500 'Human genes: SGKL, serum/ glucocorticoid regulated kinase family, member 3; XIST, X (inactive)-specific transcript; CPNE3, copine 111; ECGF1, endothelial cell growth factor 1 (platelet-derived); STX16, syntaxin 16; DICERI, Dicerl, Dcr-1 homolog (Drosophila); CASPSAP2, CASPS-associated protein 2; SAS10, disrupter of silencing 10; ADD3, adducin
3 (y); EIFIAY, eukaryotic translation initiation factor 1A, Y-linked; KPS4Y1, ribosomal protein S4, Y-linked 1; DDX3Y, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked.