adducin

ad·du·cin

(ă-dū'sen),
A membrane protein that binds to spectrin and actin and links the spectrin assembly.
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2 P16452 Not identified 4 Catalase P04040 KVWPHKDYPL (Tyr 308) 5 P55 Q00013 AIRSQYAHYF (Tyr 429) 6 Actin P60709 GRDLTDYLMK (Tyr 188) 7 G3PDH P04406 PFIDLNYMVY (Tyr 42) 8 Beta spectrin P11277 ERTSPVSLW (Ser 2114) 9 Ankyrin P16157 DQVVESPAIP (Ser 856) 10 Alpha Adducin P35611 REKSKKYSDV (Ser 408) 11 Beta Adducin P35612 TPSFLKKSKK (Ser 713) 12 Protein 4.
Independent of calpain, the researchers also found that host PKC played an important role in the loss of protein adducin from the host cytoskeleton, contributing greatly to its collapse.
Role of the adducin family genes in human essential hypertension.
Studies of the Milan hypertensive (MHS) rat and of humans with essential hypertension suggest that genetic alterations in adducin may contribute to hypertension (1).
Adducin is a heterodimeric cytoskeleton protein that consists of [alpha]-, [beta]- and [gamma]- similar subunits.
Hypertension-associated point mutations in the adducin alpha and beta subunits affect actin cytoskeleton and ion transport.
Evidence for an interaction between adducin and Na+-K+-ATPase: Relation to genetic hypertension.
Results for gene expression were 2558) genes expressed in all 10 samples, 2629 genes expressed in all 5 samples from male donors, 3343 expressed in all 5 samples from female donors, and 4013 unique genes (from a total of 8500 'Human genes: SGKL, serum/ glucocorticoid regulated kinase family, member 3; XIST, X (inactive)-specific transcript; CPNE3, copine 111; ECGF1, endothelial cell growth factor 1 (platelet-derived); STX16, syntaxin 16; DICERI, Dicerl, Dcr-1 homolog (Drosophila); CASPSAP2, CASPS-associated protein 2; SAS10, disrupter of silencing 10; ADD3, adducin 3 (y); EIFIAY, eukaryotic translation initiation factor 1A, Y-linked; KPS4Y1, ribosomal protein S4, Y-linked 1; DDX3Y, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked.