adducin

ad·du·cin

(ă-dū'sen),
A membrane protein that binds to spectrin and actin and links the spectrin assembly.
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References in periodicals archive ?
Independent of calpain, the researchers also found that host PKC played an important role in the loss of protein adducin from the host cytoskeleton, contributing greatly to its collapse.
Studies of the Milan hypertensive (MHS) rat and of humans with essential hypertension suggest that genetic alterations in adducin may contribute to hypertension (1).
Adducin is a heterodimeric cytoskeleton protein that consists of [alpha]-, [beta]- and [gamma]- similar subunits.
Hypertension-associated point mutations in the adducin alpha and beta subunits affect actin cytoskeleton and ion transport.
Evidence for an interaction between adducin and Na+-K+-ATPase: Relation to genetic hypertension.
Adducin polymorphism detection and impact on hypertension and related disorders.
Results for gene expression were 2558) genes expressed in all 10 samples, 2629 genes expressed in all 5 samples from male donors, 3343 expressed in all 5 samples from female donors, and 4013 unique genes (from a total of 8500 'Human genes: SGKL, serum/ glucocorticoid regulated kinase family, member 3; XIST, X (inactive)-specific transcript; CPNE3, copine 111; ECGF1, endothelial cell growth factor 1 (platelet-derived); STX16, syntaxin 16; DICERI, Dicerl, Dcr-1 homolog (Drosophila); CASPSAP2, CASPS-associated protein 2; SAS10, disrupter of silencing 10; ADD3, adducin 3 (y); EIFIAY, eukaryotic translation initiation factor 1A, Y-linked; KPS4Y1, ribosomal protein S4, Y-linked 1; DDX3Y, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked.
The original KPSS Phospho-Site Screen previously uncovered promising research leads, such as a 150-fold increase in the phosphorylation of adducin found in the spinal cord of ALS patients compared to patient matched controls.
The first phosphoprotein screen has uncovered promising research leads in important disease states, such as a 150-fold increase in the phosphorylation level of adducin found in the spinal cord of ALS patients compared to patient matched controls.