addressins

addressins

Components in cell membranes that mediate adhesion to particular molecules on the surfaces of other cells. They function to effect cell-to-cell interactions and to help in the distribution of cells within an organism.
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The HEV sialomucins are also called peripheral node addressins (PNAds), because they function as "address code" molecules for peripheral node HEVs.
The molecular cues regulating immune cell trafficking
They express high levels of CD44 and lack homing addressins (L-selectin and CCR7) [114,116,117]; thus, they are not circulating T cells and can be found in nonlymphoid tissues.
Skin Immune Landscape: Inside and Outside the Organism
L-selectin expressed on most leukocytes binds to ligands on endothelial cells and on other leukocytes; however, these molecules like the peripheral node addressins and the CD34 family of transmembrane sialomucins, such as podocalyxin, are not a part of this review.
The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression
For example, the specialized endothelial cells that line the high endothelial venules in lymph nodes and Peyer's patches constitutively express so-called addressins (mucosal vascular addressin cell adhesion molecule 1 [MAdCAM-1]), which support the homing of naive lymphocytes, whereas endothelial cells elsewhere permit no leukocyte binding unless they are exposed to inflammatory mediators.
Lymphocyte adhesion and autoimmunity
The activation, recruitment and retention of immune cells in the genital mucosa involve obligatory and intimate interactions between the pathogen and accessory molecules such as addressins, chemokine receptors, integrins, adhesion molecules on the host cells.
Friday's Sessions. (Abstracts of Presented Papers and Posters)

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