General Procedure for the Michael Addition Reaction
of Indole with Pyrrole Catalyzed by Feist's Acid (G[P.sub.2]).
Therefore, we showed the diastereoselective synthesis of S,S-2-methylsulfanyl-2-methylsulfinyl-1indanol (7) by reduction reaction using 2-methylsulfanyl-2-methylsulfinyl-1-indanone (9) optically enriched demonstrating the high efficiency of the sulfoxide group on the control of asymmetric induction in the carbonyl addition reaction
When the reaction was performed using [Br.sub.2] as a catalyst without adding any bromoform, only isomerized product was formed with no addition reaction
taking place in all three methods.
The Michael addition reaction
between AP (37.5 g; 0.5 mole) and DEM (86.1 g; 0.5 mole) was performed by adding the maleate dropwise under a nitrogen environment to the aminoalcohol at 60[degrees]C over 7 h.
After screening many temperature systems, we pursued the addition reaction
of oleic acid by the [1, 3, 4] thiadiazde derivatives at temperature systems in detail.
Van Koten, "Diaminoarylnickel(II) "pincer" complexes: mechanistic considerations in the kharasch addition reaction
, controlled polymerization, and dendrimeric transition metal catalysts," Accounts of Chemical Research, vol.
Nevertheless, the potential Michael addition reactions
cannot be ruled out because each BTA molecule contains two >NH groups and one >[CH.sub.2] group and the active hydrogen atoms of these functional groups may lake part in the polymerization of BMI with BTA via the Michael addition reaction
Melamine is a good nucleophile; the addition reaction
with the electrophilic formaldehyde occurs under most pH conditions, although the reaction rate is slower at neutral pH.
Moreover, Compound 135 reacted easily with urea in AcOH to afford 2,4-diaminopyrimidobenzothiazepine 147 (65% yield) via cyclo-condensation addition reaction
In the second step, the enamine A attack to aromatic aldehydes (addition reaction
) to give intermediates B, which further undergoes dehydration reaction to give 1,6-naphthyridine 3 (Step 3).
Hydrosilylation, which is the addition reaction
of a hydride terminated silane compound to a multiple bond , has been recently investigated as a possible method for polymer functionalization in solution .
Caption: FIGURE 4: Energy profiles for competitive channels of oxidative addition reaction