adaptive trial


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adaptive trial

A form of research in which data analyzed as the trial progresses are used to reshape or refocus its design.
See also: trial
References in periodicals archive ?
Aptiv Solutions' portfolio includes the Addplan software that supports the design, simulation and analysis of adaptive trials and Niphix, a full-service, oncology-focused clinical research organisation (CRO) serving both Japanese and international customers that will be integrated in Icon's existing activities in Tokyo and Osaka.
He assists companies designing and implementing adaptive trial methodologies that improve device and drug development programs by reducing clinical trial cycle times and optimizing late stage trial success rates.
Food and Drug Administration (FDA) website and the agency's Center for Devices and Radiological Health indicated it is very receptive to adaptive design, having reviewed 120 adaptive trials in the last five years.
Importantly, an adaptive trial design may provide a framework for the codevelopment of drugs and companion diagnostics in the early clinical setting, with identification of relevant biomarkers and their subsequent clinical qualification.
Despite their well-perceived advantages, the adaptive trials are complex to design, require more upfront planning, and are often met with statistical, procedural, logistic and regulatory challenges.
"By using an adaptive trial design, we may have the potential to enroll fewer patients than with a traditional approach, thus potentially accelerating the transition into phase 3 studies."
Introductory Adaptive Trial Designs: A Practical Guide With R
According to ICON, Aptiv's adaptive trial capabilities, combined with its existing technology platforms, such as ICONIK and Firecrest, will further differentiate its services and help is customers take time and cost out of the development process.
Aptiv Solutions' adaptive trial capabilities will further differentiate and enhance our services to help our customers identify the most promising drug candidates earlier.
Aptiv Solutions'adaptive trial capabilities will further differentiate and enhance our services to help customers identify the most promising drug candidates earlier.
Biopharmaceutical and medical device development services company Aptiv Solutions announced on Tuesday the latest release in its proprietary suite of adaptive trial software: ADDPLAN 6.0 PE.

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