Contribution of
adaptive thermogenesis to the hypothalamic regulation of energy balance.
In addition, type 2 idothyronine deiodinase (D2) is the primary enzyme responsible for the rapid increases in intracellular T3 and preservation of T3 as serum T4 decreases, which is essential for
adaptive thermogenesis of BAT [4].
The role of nonshivering or
adaptive thermogenesis (the generation of heat through uncoupling of mitochondrial respiration) in total energy expenditure is now being appreciated [5], with obese individuals demonstrating a reduced adaptive thermogenic capacity [6].
Nuala Byrne, the study's lead author suggests that partaking in diet resting periods helps to combat
adaptive thermogenesis, which previous studies have proven "creates the ideal situation for weight regain" after dieters have lost initial weight.
Towards a molecular understanding of
adaptive thermogenesis. Nature.
Adaptive thermogenesis of the liver in tree shrew (Tupaia belangeri) during cold acclimation.
On the other hand, it recently was observed that the
adaptive thermogenesis is not commonly associated to a chronic treatment with IL-4 in mice.
In contrast, thermogenic adipose tissue defends against hypothermia and obesity through
adaptive thermogenesis mediated by the regulated expression and activity of mitochondrial uncoupling protein 1 (UCP1).
PGC-1[alpha] plays a central role not only in
adaptive thermogenesis through the upregulation of UCP-1 in BAT, but also in gluconeogenesis in liver and fiber type switching in muscle [15, 16].
Association of bovine carcass phenotypes with genes in an
adaptive thermogenesis pathway.
Leibel, "
Adaptive thermogenesis in humans," International Journal of Obesity, vol.
Researchers call this excessive slowdown "
adaptive thermogenesis," although they don't fully understand why the body's internal furnace sometimes changes efficiency in what seems to be an effort to minimize weight loss.