adaptin

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a·dap·tin

(ă-dap'tin),

A multisubunit complex of proteins that has a binding site for the cytoplasmic aspect of cargo receptor molecules as well as a binding site for clathrin molecules, thus facilitating the formation of a clathrin coat around a vesicle; currently, four different types of adaptins are known, each capable of binding with the cytoplasmic aspect of the four different types of cargo receptors.

[adapt + -in]

adaptin

Any of the receptor-specific proteins (alpha, beta, mu and sigma) that mediate clathrin-coated pit formation, which is critical to clathrin-coated vesicle-mediated intracellular transport of proteins through membrane-bound receptor interaction. Adaptins cluster to form an AP2–complex.

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References in periodicals archive ?

The clathrin adaptor AP-2 is a heterotetrameric complex formed by [alpha], [beta]2, [mu]2, and [sigma]2 adaptin subunits and has critical functions in the assembly and recruitment of cargo proteins to clathrin-coated pits.

Thrombin-Induced Calpain Activation Promotes Protease-Activated Receptor 1 Internalization

In TGN, coat proteins, including AP-1 adaptin, form clathrin-coated pits and then transport vesicles to endosome.

Intracellular lectins are involved in quality control of glycoproteins

The N-terminus of CD2AP contains a Src homology 3 (SH3) domain and functions as an adaptin. CD2AP interacts with podocin and nephrin via its C-terminus, locating its anchor within lipid rafts in order to preserve the functions of the cytoskeleton and SD.

Yi Qi Qing Re Gao attenuates podocyte injury and inhibits vascular endothelial growth factor overexpression in puromycin aminonucleoside rat model

Viewed this way, the measured similarities among the versions of organelle proteins such as Rab, SNARE, and Adaptin suggest they all evolved from a compartment in an ancestral cell that lived long before multicellular life arose, Devos and Dacks say.