adaptin

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a·dap·tin

(ă-dap'tin),

A multisubunit complex of proteins that has a binding site for the cytoplasmic aspect of cargo receptor molecules as well as a binding site for clathrin molecules, thus facilitating the formation of a clathrin coat around a vesicle; currently, four different types of adaptins are known, each capable of binding with the cytoplasmic aspect of the four different types of cargo receptors.

[adapt + -in]

adaptin

Any of the receptor-specific proteins (alpha, beta, mu and sigma) that mediate clathrin-coated pit formation, which is critical to clathrin-coated vesicle-mediated intracellular transport of proteins through membrane-bound receptor interaction. Adaptins cluster to form an AP2–complex.

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References in periodicals archive ?

0E-8 Homo sapiens Golgi associated, gamma adaptin ear containing, ARF binding protein 1 (GGA1) NM_000527 2.

Down-regulation of single-stranded DNA-binding protein 1 expression induced by HCMV infection promotes lipid accumulation in cells

By contrast, AP-2 adaptin binds to CI-MPR on cell surfaces and forms endocytic vesicles in combination with other different coat proteins.

Intracellular lectins are involved in quality control of glycoproteins

Viewed this way, the measured similarities among the versions of organelle proteins such as Rab, SNARE, and Adaptin suggest they all evolved from a compartment in an ancestral cell that lived long before multicellular life arose, Devos and Dacks say.