adamantinoma


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ameloblastoma

 [ah-mel″o-blas-to´mah]
a locally invasive, highly destructive tumor of the jaw; called also adamantinoma.
pituitary ameloblastoma craniopharyngioma.

ad·a·man·ti·no·ma

(ad'-ŏ-man-ti-nō'mă),
1. A low-grade malignant tumor of long bones (predominantly tibia) marked by a proliferation of nests of basaloid cells with palisading at the periphery. Compare: ameloblastoma.
2. A rare, slow-growing but locally aggressive tumor; its histogenesis remains controversial. Approximately 200 cases have been reported since it was first described in 1913. The tumor occurs almost exclusively in the long bones; tumors in the tibia account for more than 80% of cases. The diaphysial region is the area most commonly affected. The histiologic features of adamantinomas have many variations that are present not only among patients but also among different areas of the same tumor. Metastases occur in approximately 15-20% of patients and typically appear in the lungs and local lymph nodes.

adamantinoma

/ad·a·man·ti·no·ma/ (ad″ah-man″tĭ-no´mah) ameloblastoma.

adamantinoma, adamantoblastoma

adamantinoma

An extremely rare, generally indolent malignant epithelial tumour, which arises almost exclusively in the tibia or fibula in the second to fifth decade in life.

Clinical findings
Swelling, pain, developing over months to years.

Imaging
Eccentric, well-circumscribed, and lytic lesion on plain films.

DiffDx
Osteofibrous dysplasia, fibrous dysplasia, aneurysmal bone cyst, chondromyxoid fibroma, chondrosarcoma.

Management
Wide resection or amputation.

Prognosis
Excellent; overall survival is 85% at 10 years, but lower without adequate margins. Metastases are rare at presentation but may occur in up to 30% of patients during the disease course.

am·e·lo·blas·to·ma

(am'el'ō-blas-tō'mă)
A benign odontogenic epithelial neoplasm; it behaves as a slowly growing expansile radiolucent tumor, occurs most commonly in the posterior regions of the mandible, and has a marked tendency to recur if inadequately excised.
[ameloblast + G. -oma, tumor]

adamantinoma (adəman´tinō´mə),

adamantinoma

see ameloblastoma, acanthomatous epulis.
References in periodicals archive ?
5] Fischer in 1913 gave the same name to a primary bone neoplasm with a marked predilection for the tibia because of its histologic resemblance to Adamantinoma of the jaw bones.
Bir calismada izlemde tekrarlanan biyopside adamantinoma saptanmasi nedeniyle butun osteofibroz displazi tanili olgulara ekstraperiostal eksizyon onerilmektedir (11).
Background: Adamantinomas are extremely rare, locally aggressive and/or malignant lesions composed of epithelial-like cells in a dense fibrous stroma.
Tumors That Frequently or Rarely Coexpress Cytokeratin and Vimentin Carcinomas that frequently express both Anaplastic thyroid carcinoma Endometrial carcinoma Mesothelioma Metaplastic breast carcinoma Myoepithelial carcinoma Renal cell carcinoma Sarcomatoid carcinoma Thyroid carcinomas Mesenchymal tumors that frequently express both Adamantinoma Chordoma DPSRCT Epithelioid angiosarcoma Epithelioid sarcoma Leiomyosarcoma Malignant rhabdoid tumor Synovial sarcoma Carcinomas that rarely express both Breast carcinoma GI carcinoma Lung, non-small cell carcinoma Ovarian carcinoma Prostatic carcinoma Small cell carcinoma Abbreviations: DPSRCT, desmoplastic small round cell tumor; GI, gastrointestinal.
The differential diagnosis of FD on radiograph varies based on location but includes nonossifying fibroma, osteofibrous dysplasia, aneurysmal bone cyst, adamantinoma, giant cell tumor, and low-grade central osteosarcoma.
Cartilage Tumors Chondrosarcoma Central, primary, and secondary Peripheral Dedifferentiated Mesenchymal Clear cell Osteogenic Tumors Osteosarcoma Conventional Chondroblastic Fibroblastic Osteoblastic Telangiectatic Small cell Low-grade central Secondary Parosteal Periosteal High-grade surface Fibrogenic Tumors Fibrosarcoma Fibrohistiocytic Tumors Malignant fibrous histiocytoma (undifferentiated pleomorphic sarcoma) Ewing Sarcoma/Primitive Neuroectodermal Tumor Hematopoietic Tumors Plasma cell myeloma Malignant lymphoma, not otherwise specified (NOS) Giant Cell Tumors Malignancy in giant cell tumor Notochordal Tumors Chordoma Vascular Tumors Angiosarcoma Smooth Muscle Tumors Leiomyosarcoma Lipogenic Tumors Liposarcoma Miscellaneous Tumors Adamantinoma Metastatic malignancy
Next, the article addresses adamantinoma, a primary bone tumor with true epithelial differentiation.
Adamantinoma-like EFT has been described in the tibia and fibula and shares histological and immunohistochemical features of adamantinoma, such as distinct nests of moderately pleomorphic tumor cells with peripheral palisading, a prominent desmoplastic host response, and positive immunohistochemistry for cytokeratins.
Epithelioid and epithelial neoplasms seen in bone are rare and include epithelioid variants of vascular lesions, osteoblastoma, osteosarcoma, chordoma, and chondroblastoma as well as adamantinoma and metastatic carcinoma.
This notion is bolstered by studies showing that the composition of the extracellular matrix of soft tissue and bone tumors with a biphasic epithelial and mesenchymal phenotype, such as synovial sarcoma (10) and adamantinoma of long bone, (11) varies according to the type of tissue (epithelial or mesenchymal) the stromal matrix associates.
Topics include new insights from gene expression profiling into human hepatocellular carcinoma, germline and somatic mutations in colorectal cancers from patients with hereditary nonpolyposis colorectal cancer, lung cancer screening, progress in the prevention of colorectal cancer, diagnosis and therapy of long-bone adamantinomas, the effects of physical activity in protection against colorectal cancer, the importance of EGFR in tumorigenesis from preneoplastic bronchial lesions to invasive lung cancer, the usefulness of anal endosonography in the assessment of anal carcinoma, and acute phase reactants in hemodialysis and renal transplantation.