ATR-101 is a selective inhibitor of ACAT1 (acyl-CoA: cholesterol acyltransferase
1), an enzyme that catalyzes the transformation of free cholesterol into cholesterol ester, the starting point for adrenal steroid synthesis.
The toxic effects of enniatin are caused by the inhibition of the acyl-CoA cholesterol acyltransferase
, depolarization of mitochondria, and inhibition of osteoclastic bone resorption.
1]), lysophospholipase, neutral lipid lipase, or even transacylase/ acyltransferase
reaction rather than or in addition to the genuine [PLA.
1), 1-acyl-sn-glycerol-3-phosphate acyltransferase
(192 aa; locus tag SAMN05421737_105218; accession number FMYM01000005.
The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase
activity with high fat feeding.
A key event in the RCT pathway is the esterification of cholesterol by lecithin-cholesterol acyltransferase
Most of these enzymes encountered little change in their expression levels, except for phosphatidate phosphatase (PP) and diacylglycerol acyltransferase
Primers for the expression analysis of different genes were shown in Table 1, including genes involved in hepatic lipid intake, like CD36; genes related to lipid synthesis, like diacylglycerol acyltransferase
2 (DGAT-2), SREBP-1c and its downstream gene acetyl-CoA carboxylase 1 (ACC-1), fatty acid synthase (FAS) and stearoyl-CoA desaturase 1 (SCD-1); genes in response to lipid catabolism, like PPAR[alpha] and its downstream gene carnitine palmitoyl transferase 1a (CPT-la), acyl-CoA oxidase 1 (ACOX-1); as well as gene function to lipid outflow like apoB100.
Target cell is believed to be due to decreased red cell volume as seen in haemoglobinopathies and iron deficiency or increased red cell membrane as in liver cholestasis, lecithin:cholesterol acyltransferase
(LCAT) deficiency and post splenectomy state.
Alterations in high-density lipoprotein metabolism and reverse cholesterol transport in insulin resistance and type 2 diabetes mellitus: Role of lipolytic enzymes, lecithin: Cholesterol acyltransferase
and lipid transfer proteins.
Characterization of cultivar differences in alcohol acyltransferase
and 1-aminocyclopropane-1-carboxylate synthase gene expression and volatile ester emission during apple fruit maturation and ripening.
Firstly, due to the down regulation of lecithin-cholesterol acyltransferase
(LCAT), maturation of HDL is impaired.