acyl-CoA synthetase

ac·yl-CoA syn·the·tase

1. general term for enzymes that form acyl-CoA, now called ligases;
2. specifically, long-chain fatty acid-CoA ligase.
Farlex Partner Medical Dictionary © Farlex 2012

acyl-CoA synthetase

(1) Long-chain-fatty-acid-CoA ligase, EC 6.2.1.3 (long-chain-fatty-acid-CoA:ligase (AMP-forming)).
(2) Any enzyme that forms acyl-CoA, ligases (EC 6.2.1.x).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Acyl-CoA synthetase long-chain family member 1 has demonstrated roles in animal fat synthesis and fatty P-oxidation and might be associated with fat deposition and meat quality traits [23].
Genes encoding long-chain acyl-CoA synthetase (IDG010) and fatty aldehyde decarbonylase (CER1, IDG045), the two enzymes involved in the plant alkane-forming pathway [87], were coexpressed in the wheat stamen.
Acyl-CoA synthetase 5 (ACS5) gene encodes an enzyme involved in fatty acid degradation and lipid biosynthesis [3].
Coleman, "Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently," Journal of Biological Chemistry, vol.
Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglycerol in McArdle-RH7777 cells.
Additionally, an increase in the enzymes present in the metabolism of fatty acids, such as Acetyl-CoA Synthetase (ACeCS1) and Acyl-CoA Synthetase (ACSL1), and an induction of oxidative stress were observed.
ACSL6 encodes for acyl-CoA synthetase long-chain family member 6, a protein that catalyzes formation of acyl-CoA from fatty acids.
Primer sequences for acetyl-CoA acyltransferase (ACAA2), long-chain acyl-CoA dehydrogenase (ACADL), acyl-CoA synthetase (ACSL1), very long chain acyl-CoA dehydrogenase (ACADVL), carnitine palmitoyltransferase 1B (CPT1B), enoyl-CoA hydratase (ECH1), hydroxyacyl-CoA dehydrogenase (HADHA), pyruvate dehydrogenase kinase (PDK4), PGC-1[alpha], PGC-1[beta], PPAR[alpha], glutamate dehydrogenase, and 18S ribosomal RNA are available in Supplemental Material, Table S1 (http://dx.doi.org/10.1289/ehp.1205056).
FA are activated by acyl-CoA synthetase on the peroxisomal membrane and the entry into the organelle is independent ofcarnitine.
This requires their activation by long chain fatty acyl-CoA synthetase, on the outer mitochondrial membrane, to generate long chain fatty acyl-CoA.
The acyl residues are exported to the cytoplasm and converted to acyl-CoA esters by acyl-CoA synthetase, thereby producing substrates that are further elongated in species that produce VLCs and further desaturated in species that produce polyunsaturated fatty acids.
Jenks, "Arabidopsis CER8 encodes LONG-CHAIN ACYL-COA SYNTHETASE 1 (LACS1) that has overlapping functions with LACS2 in plant wax and cutin synthesis," Plant Journal, vol.

Full browser ?