acute-phase serum


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acute-phase serum

Serum from a patient with a current (acute) infection for which bacterial- or viral-specific immunoglobulins (usually IgM) are measured.
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A total of 23/38 patients positive for IgM against WNV provided convalescent-phase serum samples (obtained 18-83 days after acute-phase serum samples were obtained).
IgG (titer [greater than or equal to] 160) in acute-phase serum defined rickettsial exposure (seroprevalence).
Studies in neighboring regions have used flawed methods, including spectrum bias, small sample size, selective enrollment, and testing acute-phase serum only.
We obtained acute-phase serum samples from 24 patients given a clinical diagnosis of SFTS and analyzed these samples SFTSV RNA by using RT-PCR and for SFTSV antibodies by using ELISA.
Detection of Virus RNA in Acute-phase Serum Samples
Because we lacked sufficient blood samples, we did not analyze HI in acute-phase serum.
IgG against H1 and H3 was detected in the acute-phase serum (GMT 1,114.
Furthermore, we used dengue virus neutralization testing to confirm the specific presence of dengue in a subset of IgG-positive serum samples in addition to performing PCR and viral isolation on the acute-phase serum samples of patients with serologically confirmed acute dengue.
Furthermore, we found that testing acute-phase serum specimens for IgM has multiple limitations for the diagnosis of acute leptospirosis, because a positive result more often denoted past infection than an acute infection, and results were negative early in infection.
Acute-phase serum samples were tested by real-time PCR for DENV RNA, according to the diagnostic criteria for dengue fever enacted by the Chinese Ministry of Health.
Acute-phase serum samples were collected at the time of enrollment and convalescent-phase serum samples 3-5 weeks later.
Diagnostic tests for ZIKV infection include PCR tests on acute-phase serum samples, which detect viral RNA, and other tests to detect specific antibody against ZIKV in serum.