acute tubulointerstitial nephritis
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acute tubulointerstitial nephritisA condition characterised by tubular damage leading to renal tubular dysfunction, which is generally reversible and is attributed to the regenerative capacity of tubules with preserved basement membrane.
Drugs—NSAIDs, antibiotics, rifampin, allopurinol, IFN-alpha, PPI inhibitors, TINU (tubuloinerstitial nephritis and bilateral uveitis); granulomatous inflammation—e.g., sarcoidosis.
Patients generally present abruptly with rash, fever, eosinophilia, eosinophiluria, and elevated IgE. In cases linked to NSAIDs, acute disease follows months of NSAID use.
Hypersensivity reaction to drugs or bacteria/viruses.