acute retinal necrosis


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acute retinal necrosis (ARN),

a viral syndrome occurring in immunocompetent patients, characterized by peripheral retinal destruction that becomes circumferential and leads to retinal detachment.

Acute Retinal Necrosis

An uncommon (2%–5%) condition characterised by herpes virus-induced anterior and posterior uveitis, papillitis with retinal detachment 1 to 3 months after onset, of which half are bilateral.
Aetiology ARN is linked to dormant herpes simplex virus 1, HSV-2, or varicella-herpes zoster virus reactivation in the retina.
Clinical findings Red eye, periorbital pain, hazy vision, history of prior herpes infection, episcleritis, keratic precipitation, occlusive retinal vasculitis.

a·cute ret·i·nal ne·cro·sis

(ARN) (ă-kyūt' ret'i-năl nĕ-krō'sis)
A viral syndrome occurring in immunocompetent patients, characterized by peripheral retinal destruction that becomes circumferential and often leads to retinal detachment

retinal necrosis, acute 

A necrotizing retinitis caused by the varicella-zoster virus or herpes simplex virus types 1 and 2, which may infect healthy individuals of any age. The patient usually presents with ocular discomfort, reduced visual acuity and floaters. The signs are those of anterior granulomatous uveitis. There are typically many areas of retinitis, which eventually coalesce ending in full thickness retinal necrosis. Treatment is with antiviral agents, followed by systemic steroids.
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References in periodicals archive ?
Antiviral selection in the management of acute retinal necrosis. Clin Ophthalmol.
Four cases of bilateral acute retinal necrosis with a long interval after the initial onset.
Acute retinal necrosis (ARN) was suspected and the patient was advised to have immediate aqueous and vitreous taps, followed by intravitreal ganciclovir 2 mg/0.1 ml injection and dexamethasone 0.4mg/0.1ml injection of the right eye.
Dix, "Treatment of the acute retinal necrosis syndrome with intravenous acyclovir," Ophthalmology, vol.
Association of herpes zoster ophthalmicus with AIDS and acute retinal necrosis. Am J Ophthalmol.
Dupont, "Acute retinal necrosis in the course of AIDS: study of 26 cases," AIDS, vol.
Posterior segment lesions Number of Percentage of Percentage patients total patients of posterior segment lesions (n = 25) HIV retinopathy 7 17.5 28 CMV retinitis 5 12.5 20 Toxoplasma 3 7.5 12 Retinal detachment 3 7.5 12 Retinal vascular 2 5 8 occlusions Retinopathy of anaemia 2 5 8 Tubercular 1 2.5 4 chorioretinitis Acute retinal necrosis 1 2.5 4 Endogenous 1 2.5 4 endophthalmitis TABLE 4: Neuroophthalmic lesions.
(26) did not find any significant difference between the serum and aqueous humor levels of TNF-[alpha] in patients with anterior herpes simplex uveitis, acute retinal necrosis, and Vogt-Koyanagi-Harada uveitis.
Other viral conditions such as cytomegalovirus retinitis and herpetic acute retinal necrosis are typically aggressive and unremitting, and resolution results in retinochoroidal pigmentary changes or retinal detachment.
Acute retinal necrosis, ARN, is a rather infrequent entity, characterized by retinitis, vasculitis, hemorrhages and areas of retinal necrosis associated to uveitis and optic neuritis, which is not restricted to immune compromised people (1).
The first is acute retinal necrosis (a rapid deterioration of the retina) that can occur at any stage of HIV infection.

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