acute phase reactants

a·cute phase re·ac·tants

a group of proteins that are produced and/or released in increased concentrations during the acute phase reaction, including fibrinogen; C-reactive protein; complement proteins B, C3, C4; α2-acid glycoprotein, serum amyloid A, and proteinase inhibitors.

Acute phase reactants

Blood proteins whose concentrations increase or decrease in reaction to the inflammation process.
References in periodicals archive ?
The 3p and 14q LOH were the characteristics of ccRCC with elevated acute phase reactants, including PIS, regardless of the presence of metastasis.
His clinical attacks decreased after anakinra treatment, but still his levels of acute phase reactants were high.
Objective: To analyze the acute phase reactants in patients suffering from rheumatoid arthritis (RA) and compare them to healthy controls.
Increased acute phase reactants and leukocytosis were the most common laboratory findings.
It has been proposed that megakaryopoesis is affected with excessive production of proinflammatory cytokines and acute phase reactants and platelets with a small volume are released from the bone marrow in the advanced stages of inflammation (7).
8 CRP and albumin are together acute phase reactants, of which CRP is positive APR (acute phase reactant) while albumin is negative APR.
In recent times, significant attention has been paid to the study of acute phase reactants in patients with Chronic Renal Failure (CRF) undergoing haemodialysis.
Because the apoSAAs are acute phase reactants, the liver has been considered to be the primary site of expression, where they are induced by inflammatory cytokines IL-1 and IL-6 and TNF[alpha] (MEEK et al.
3-8) Laboratory tests should also show an elevated erythrocyte sedimentation rate and a higher number of acute phase reactants during the attacks, with these remaining at normal levels between the attacks.
Diagnostic difficulties in CAP cases generally necessitate the evaluation of multiple factors to differentiate viral and bacterial etiology, such as patient age, disease progression, accompanying symptoms, serum biomarkers, serum acute phase reactants, radiological findings, presence of viral epidemics, and clinical response to antibiotics (5).
It seems that increased body adipose tissue, particularly visceral depots, is associated with increased risk of iron deficiency which may be masked by high serum ferritin levels, presumably because the increase cytokines result in increased acute phase reactants synthesis resulting in increased macrophage sequestration and/or decreased intestinal iron absorption.
Increased levels of fibrinogen, certain protein globulins, other acute phase reactants, and cholesterol may reduce the zeta potential, resulting in elevated ESR results.

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