acute phase protein


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acute phase protein

plasma proteins associated with inflammation including C-reactive protein (CRP), mannose-binding protein, serum amyloid P component, α1-antitrypsin, fibrinogen, ceruloplasmin, and complement components C9 and factor B, the concentrations of which increase in response to interleukins 1, 6, and 11.

acute phase protein

Any of the plasma proteins whose concentration increases or decreases by at least 25% during inflammation. Acute-phase proteins include C-reactive protein, several complement and coagulation factors, transport proteins, amyloid, and antiprotease enzymes. They help mediate both positive and negative effects of acute and chronic inflammation, including chemotaxis, phagocytosis, protection against oxygen radicals, and tissue repair. In clinical medicine the erythrocyte sedimentation rate or serum C-reactive protein level sometimes is used as a marker of increased amounts of acute-phase proteins. Synonym: acute phase reactant See: inflammation
See also: protein
References in periodicals archive ?
Early biomarkers of inflammation in dogs and cats: The acute phase protein. Veterinary Research Communications, v.31, n.1, p.125-129, 2007a.
[sup][1] An increasing number of inflammatory markers and acute phase proteins have been tested in CAD, and their plasma levels have been confirmed to be correlated with different clinical characteristics and the prognosis of these patients.
Nevertheless, elevation of both acute phase proteins was a poor prognostic sign and the results emphasize the importance of monitoring levels of these proteins on admission, during management and before discharge.
This phenomenon is known as the 'acute phase response'; one of its features is the production in the liver of 'acute phase proteins (APP)'.
Vilcek, "TSG-14, a tumor necrosis factor-and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins," The Journal of Immunology, vol.
Caption: Figure 3: Prohepcidin and acute phase protein levels during anti-TNF therapy in CD patients.
The acute phase protein serum amyloid A (SAA) as a marker of inflammation in horses.
It can confirm an increase in IL-6 concentration corresponding with a little elevation of AGP concentration as acute phase protein. A 2-fold increase in the concentration of determined acute phase proteins (AAT and AGP) in the blood of AP patients was also demonstrated.
In particular, a decrease in the prealbumin fraction may be an important early indicator; however, further investigations are necessary to identify the appropriate standardized methods to distinctively identify the electrophoretographic fractions and elucidate the significance of this potential negative acute phase protein in the diagnosis of aspergillosis in birds.
Haptoglobin (Hp), a hemoglobin binding protein, is a representative acute phase protein (APP) in cattle, which is stimulated by inflammatory mediators and produced by liver.
The novel acute phase protein, IHRP, inhibits actin polymerization and phagocytosis of polymorphonuclear cells.
Serum Amyloid A is recognized as the most acute phase protein in horses and may increase by 10 to 100 times in inflammation, reaching values above 20,000ng [mL.sup.-1] (HINCHCLIFF et al., 2004; HOBO et al., 2007).

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