acute panmyelosis with myelofibrosis

acute panmyelosis with myelofibrosis

An aggressive form of acute myeloid leukaemia, in which the bone marrow is seriously damaged due to either a clonal expansion or toxic exposure, resulting in pancytopenia and poor prognosis (median survival post-diagnosis: 9 months).

acute panmyelosis with myelofibrosis

,

APMF

A form of acute leukemia in which multiple cell lines develop aberrantly, infiltrate internal organs, e.g., the spleen, and cause extensive bone marrow fibrosis.
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In addition, when there is leukoerythroblastosis in the peripheral blood along with increased fibrosis and increased atypical megakaryocytes and megakaryoblasts, then the differential diagnosis includes acute megakaryoblastic leukemia, acute panmyelosis with myelofibrosis, and transformed primary myelofibrosis.
AML with recurrent cytogenetic translocations AML with t(8;21)(q22;q22) Acute PML with t(15;17)(q22;q21) Variant acute PML with t(v;17) AML with abnormal bone marrow eosinophils inv(16)(p13;q22) or t(16;16)(p13;q22) AML with 11q23 abnormalities AML with multilineage dysplasia With prior myelodysplastic syndrome Without prior myelodysplastic syndrome AML and myelodysplastic syndrome, therapy related Alkylating agent related Topoisomerase II inhibitor related Other types AML not otherwise categorized AML minimally differentiated AML without maturation AML with maturation Acute myelomonocytic leukemia Acute monocytic leukemia Acute erythroid leukemia Acute megakaryocytic leukemia Acute basophilic leukemia Acute panmyelosis with myelofibrosis Table 13.
Acute myeloid leukemia without maturation, acute myeloid leukemia with maturation, and the blasts of acute panmyelosis with myelofibrosis show nonspecific features, with frequent expression of markers associated with myeloid immaturity, such as CD34 and CD117, combined with variable expression of more general markers of myeloid lineage, including CD13, CD15, CD33, and CD64.