acute pancreatitis


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Related to acute pancreatitis: Chronic pancreatitis

acute pancreatitis

Etymology: Gk, pan, all, kreas, flesh, itis, inflammation
a sudden inflammation of the pancreas caused by autodigestion and marked by symptoms of acute abdomen and escape of pancreatic enzymes into the pancreatic tissues. The condition is associated with trauma, biliary disease or alcoholism. The autodigestion is caused by premature activation of the digestive enzymes. Acute pancreatitis can also be of unknown cause. See also pancreatitis.

acute pancreatitis

Inflammation of the pancreas of abrupt onset, often accompanied by gallstones and alcohol ingestion.
 
Epidemiology
15-fold increase from 1960s to present, possibly due to widened diagnostic criteria, with 40 admissions/105/year.
 
Aetiology
See table.

Clinical findings
Abdominal pain, nausea, vomiting, hypotension.

Diagnosis
Contrast-enhanced CT (method of choice), ultrasonography.

Lab
Increased amylase, increased lipase.

Management
Supportive bowel rest with parenteral nutrition.
 
Prognotic instruments
Ranson’s criteria, modified Glasgow criteria, APACHE II.
 
Prognosis
25% have complications; 9% die of pancreatitis, sepsis, pulmonary failure, etc.

Acute pancreatitis aetiology
• Acute ischaemia—thrombosis, embolism, vasculitis, shock.
• Alcohol.
• Drugs—thiazide diuretics, azathioprine, oestrogens, sulfonamides, furosemide, methyldopa, pentamidine, procainamide.
• Gallstones—biliary tract disease.
• Genetic—defective genes encoding critical enzymes or proteins.
• Infection—mumps, coxsackieviruses, Mycoplasma pneumoniae.
• Metabolic defects—hypertriglyceridemia, hyperparathyroidism, hypercalcaemia.
• Obstruction—ampullary tumours, congenital defects of pancreas or biliary tree, parasites.
• Toxins—scorpion bites.
• Trauma—blunt, iatrogenic injury during heart surgery or ERCP.
• Vascular defects.
• Idiopathic.

Pathogenesis
Autodigestion of pancreas by inappropriately activated pancreatic enzymes—e.g., trypsin from trypsinogen—which activates other proenzymes. Possible pathways of enzyme activation:
(1) Pancreatic duct obstruction
Increased intrapancreatic ductal pressure results in accumulation of enzyme-rich interstitial fluid; lipase (one of the few enzymes secreted in activated form) results in fat necrosis, while injured tissues release cytokines, leading to local inflammation, oedema.
(2) Primary acinar cell injury—e.g., mumps, other viral infections, drugs, trauma, ischaemia, shock.
(3) Defective intracellular transport of proenzymes—aberrant cell packaging of enzymes has been shown to occur in alcohol and duct obstruction.

acute pancreatitis

Inflammation of the pancreas of abrupt onset, often with gallstones and alcohol ingestion Epidemiology 109,000 hospitalizations, 2251 deaths–US; 10-fold ↑ from 1960s to 1980s–reason unclear;
? alcohol abuse; ? widened diagnostic criteria; ± 250 admissions/106 population/yr, higher in certain populations–eg, 4-22% in AIDS Pts Etiology Obstruction, toxins or drugs, trauma, metabolic defects, infection, vascular defects, idiopathic Diagnosis Abdominal pain, ↑ amylase, ↑ lipase, ultrasonography, contrast-enhanced CT Management Supportive, bowel rest with parenteral nutrition Prognosis Ranson's criteria, modified Glasgow criteria, APACHE II Prognosis 25% have complications, 9% die of pancreatitis, sepsis, pulmonary failure, etc. See Chronic pancreatitis.

a·cute pan·cre·a·ti·tis

(ă-kyūt' pan'krē-ă-tī'tis)
Inflammation of the pancreas, frequently involving destruction of tissue by pancreatic enzymes. When severe, may lead to local necrosis, hemorrhage, and shock.

Fitz,

Reginald Heber, U.S. physician, 1843-1913.
Fitz syndrome - Synonym(s): acute pancreatitis
References in periodicals archive ?
Pioglitazone attenuates the severity of sodium taurocholate-induced severe acute pancreatitis.
Cholelithiasis is the most common cause of acute pancreatitis in pregnant women [8]; however, it should be emphasized that the absence of cholesterol deposits does not necessarily preclude the presence of this condition.
For scoring, Ranson criteria, Acute Physiologic and Chronic Health Evaluation (APACHE) II criteria, Balthazar score, and Bedside Index of Severity in Acute Pancreatitis (BISAP) are used (11-14).
In present study, we investigated a total of 60 patients of Mild acute pancreatitis for effect of early oral refeeding and then assess its efficacy and safety in disease management by calculating Total length of hospital stay of patients.
The CT scan was used to determine the presence of local complications of acute pancreatitis such as pancreatic necrosis, peripancreatic fluid collections and pancreatic ascites, and to confirm the diagnosis of pancreatitis when this was doubtful.
An ideal laboratory test in the evaluation of a patient with acute pancreatitis (AP) should, in addition to accurately establishing the diagnosis of AP, provide early assessment of its severity and identify the aetiology5.
Mark Z Simmons et al [11] suggested the importance of CT scan of abdomen in identifying minimum pleural effusions in patients with acute pancreatitis and having history of alcohol intake.
Acute pancreatitis is an inflammatory condition of the pancreas that currently has no disease-modifying therapy.
Prospective comparison of C-reactive protein level, Ranson score and contrast-enhanced computed tomography in the prediction of septic complications of acute pancreatitis.
Acute pancreatitis is among the most common gastrointestinal causes of inpatient admission to U.

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