For example, a patient with bipolar disorder who has acute mania
and psychosis may require significant doses of both a mood stabilizer and an antipsychotic.
They had enrolled a group of 66 patients who were hospitalized for acute mania
and gave half of them probiotic supplements and the others placebos to take at home after they were discharged for the following 24 weeks.
Methylphenidate ineffective for treatment of acute mania
Pharmacotherapy is the treatment of choice for acute mania
, with the goal of rapid control of dangerous behaviour, aggression, and agitation.
There has been growing interest in the reproductive safety of these medicines given their use both for acute mania
and for prophylaxis of bipolar disorder; they also are used as an adjunct to treat patients with major depression.
However, in the last 10-15 years, several synthetic agents have been developed that are used for the treatment of different phases of bipolar disorder including acute mania
, acute depression, and relapse prevention [53, 56, 57].
The patient was given a diagnosis of bipolar disorder type II with current depressed mood and no evidence of acute mania
. She was started on valproic acid 250 mg po tid.
One man was a former soldier who had"acute mania
." Another was an impoverished farmer who developed dementia from malnutrition because he made sure his children ate before he did.
Olanzapine is a second-generation antipsychotic medication effective for the treatment of acute bipolar mania  and recommended for acute mania
by various guidelines across the world [27-29].
Methods: This retrospective study was performed on 76 patients with acute mania
who were admitted to the Inpatients Psychiatry Clinic of Afyon Kocatepe University Hospital in Turkey.
Similar to the APA guidelines, lithium, valproate, and a number of atypical antipsychotics are recommended as first-line therapies for acute mania
. Other recommended first-line options include adjunctive asenapine, as well as monotherapy with extended-release paliperidone, extended-release divalproex, and asenapine 
On May 1, the patient was found to have symptoms of abrupt-onset, generalized weakness in each limb in additional to acute mania
. Interestingly, nursing records revealed that the patient exercised extensively and drank 2000 cc of root beer 1-day before his onset of limb weakness.