Our suitability map may provide a detailed prediction of the risk for acute histoplasmosis
infection, including areas of new endemicity.
Our patient previously lived in Ohio and had traveled to Kansas City shortly before his illness, and both locations are endemic areas where he may have acquired acute histoplasmosis
. He was at higher risk for developing the infection as he was immunocompromised and on immunosuppressants for his RA.
Histoplasma pericarditis occurs in 6-10% of patients with acute histoplasmosis
, predominantly in younger patients [17,18].
Failure to exclude the diagnosis of histoplasmosis before treatment for a cardiac sarcoid may lead to marked disease exacerbation if immunosuppressive therapy is initiated in a patient who actually has acute histoplasmosis
Second, because of the small number of cases and lack of variability in exposures reported, data from the investigation were insufficient to determine statistically significant findings relating an exposure at the site to acute histoplasmosis
. The only exposure that was clearly associated with illness was attending the bonfire.
How to Report the Presence of Organisms.--The subtyping of infectious mycobacterial or fungal disease (acute histoplasmosis
versus histoplasmoma, progressive primary tuberculosis versus secondary tuberculosis, etc.) often requires clinical and radiographic information that is usually unavailable to the pathologist.
is acquired from inhalation of spores.
OBJECTIVE: The objective of this study was to determine the etiology and risk factors for acute histoplasmosis
in two outbreaks in Illinois among laborers at a landfill in 2001 and at a bridge reconstruction site in 2003.
A case was defined as an illness clinically compatible with acute histoplasmosis
, as determined by the authors of the original reports.
The couple, both aged 26 years, had onset of symptoms consistent with acute histoplasmosis
8 days after returning from Acapulco.
We report a cluster of 4 cases of acute histoplasmosis
(1 culture proven and 3 with positive serology, of which 2 were symptomatic) associated with exposure to soil during a golf course renovation, Patients in western Canada with compatible symptoms should be tested for histoplasmosis, regardless of their travel or exposure history.