acute febrile neutrophilic dermatosis


Also found in: Acronyms.

a·cute fe·brile neu·tro·phil·ic der·ma·to·sis

a rare dermatosis, predominant in women, of rapid onset and characterized by plaquelike lesions, usually multiple, on the face, neck, and upper extremities, accompanied by conjunctivitis, mucosal lesions, fever, malaise, arthralgia, and peripheral blood neutrophilia in many cases; biopsy reveals polymorphonuclear infiltrate of the dermis; rapid remission occurs with systemic steroid therapy.
Synonym(s): Sweet disease
An uncommon self-limited (5–12 weeks) condition characterised by single or multiple erythematous papules and plaques ± accompanied by pustules; it is more common in females; in males, it is associated with cancer including lymphoma, leukaemia, solid tumours and myeloproliferative disorders; it is also associated with ulcerative colitis, monoclonal gammopathies, rheumatoid arthritis, erythema nodosum, Sjögren syndrome, lupus erythematosus, vaccinations and various infections
Management Systemic steroids

Sweet,

Robert Douglas, 20th century English dermatologist.
Sweet disease - Synonym(s): acute febrile neutrophilic dermatosis; Sweet syndrome
Sweet syndrome - Synonym(s): Sweet disease
References in periodicals archive ?
Sweet first described acute febrile neutrophilic dermatosis in 1964.
Subcutaneous Sweet's syndrome: a variant of acute febrile neutrophilic dermatosis that is included in the histologic differential diagnosis of neutrophilic panniculitis.
(13.) Zamanian A, Ameri A: Acute febrile neutrophilic dermatosis (Sweet's syndrome): a study of 15 cases in Iran.
The differential diagnosis for EM includes urticaria, Stevens-Johnson syndrome, fixed drug eruption, bullous pemphigoid, paraneoplastic pemphigus, acute febrile neutrophilic dermatosis (Sweet's syndrome), polymorphous light eruption (PMLE), and cutaneous small-vessel vasculitis.
Neutrophilic dermatosis of the dorsal hands (NDDH), a term coined in 2000 by Galaria et al., is an entity clinically and histopathologically similar to Sweet's syndrome (acute febrile neutrophilic dermatosis) (1), (2).
Other rare categories of neutrophilic dermatoses include Sweet's syndrome, an acute febrile neutrophilic dermatosis, and neutrophilic dermatosis of the dorsum of the hand.
Sweet's syndrome (acute febrile neutrophilic dermatosis) is a reactive disorder generally considered to be a dermatologic manifestation of a systemic disease.

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