acute fatty liver of pregnancy


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Acute Fatty Liver of Pregnancy

A rare (1:10,000–15,000) idiopathic complication of pregnancy, most often affecting primiparas with male infants or twins, variably associated with pre-eclampsia.
Clinical findings Onset after 35th week—occasionally as early as the 13th week—possibly progressing to fulminant hepatic failure with jaundice, encephalopathy, DIC, death.
Prognosis ±20% mortality
Management Terminate pregnancy

acute fatty liver of pregnancy

 Fatty liver of pregnancy, see there.
References in periodicals archive ?
A retrospective study of seven cases of acute fatty liver of pregnancy. Obstet Gynecol 2013:730569.
A prospective national study of acute fatty liver of pregnancy in the UK.
Liu, "Clinical diagnosis and treatment of acute fatty liver of pregnancy: A literature review and 11 new cases," Journal of Obstetrics and Gynaecology Research, vol.
He and his associates assessed the clinical presentations and outcomes of all 16 women treated for acute fatty liver of pregnancy (AFLP) at three tertiary-care centers in Ohio and Kentucky between 1993 and 2003.
The molecular basis of pediatric long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency associated with acute fatty liver of pregnancy. Proc Natl Acad Sci U S A 1995;92:841-5.
Etiology of the disease was Hepatitis E in 28(53.8%), Hepatitis B in 9 (17.3%), Hepatitis C in 7 (13.5%) HELLP syndrome in 7 (13.5%) and acute fatty liver of pregnancy in 1 (3.57%) case.
Beniwal M et al have reported the same findings and did not find HCV associated FHF.20 The current study indicates very low frequency of acute fatty liver of pregnancy (1.9%), and same was fond by other workers.21 In our study the major complications of FHF were encephalopathy (30.8%) while Khuroo M.S found cerebral oedema (53.2%).
Some of the complications of acute fatty liver of pregnancy include diabetes insipidus, disseminated intravascular coagulopathy, spontaneous labor, and postpartum hemorrhage.
Wei Q (14) found all cases of acute fatty liver of pregnancy presented with a prodrome of nausea, vomiting, malaise and jaundice.
Acute fatty liver of pregnancy and sepsis are rarely seen etiologic factors, which might eventually result in the death of the patient.
INCIDENCE: Out of 30 patients, 10 had preeclampsia, 4 had HELLP, 2 diagnosed with acute fatty liver of pregnancy. 14 were suffering from gestational thrombocytopenia.
of cases=30 Diagnosis 10 Preeclampsia 04 HELLP 02 Acute fatty liver of pregnancy 14 Gestational thrombocytopenia.

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