acute acalculous cholecystitis

acute acalculous cholecystitis

A rare but serious condition (up to 50% mortality) affecting approximately 5% of patients undergoing cholecystectomy, in which no stones are present in the inflamed gallbladder.
 
Clinical findings
Fever, right-upper quadrant pain.

Predisposing factors
ICU, long-term TPN, diabetes, pregnancy, sepsis, hepatitis A.

Lab
CBC count, liver function tests, blood culture; bile cultures are negative in half of cases.

Pathogenesis
Uncertain, possibly bile stasis and increased lithogenicity of bile.

Management
Open or laparoscopic cholecystectomy.
References in periodicals archive ?
Acute acalculous cholecystitis (AAC) is defined as an acute necro-inflammatory disease of the gallbladder in the absence of cholelithiasis and has a multifactorial pathogenesis.
Key Words: Hepatitis A virus, Acute acalculous cholecystitis, Gall bladder wall thickness
She has published more the 10 scientific research papers in reputed medical journals that include: Cadaveric liver transplant from older donor (2008), Standard formula for liver volume in Middle Eastern Arabic adults (2010), Islam, brain death, and transplantation: Culture, faith, and jurisprudence (2012), and Acute acalculous cholecystitis perforation in a child non-surgical management (2012).
According to him, these symptoms can also be showing that the child has a condition known as 'Acute Acalculous Cholecystitis (AAC)''.
Acute acalculous cholecystitis (AAC) is a disease characterized by severe gallbladder inflammation without cystic duct obstruction due to gallstones; AAC occurs most frequently in critically ill patients and is associated with high morbidity and mortality.
He said that Acute Acalculous Cholecystitis, though rare, is most often seen in critically ill people in hospital intensive care units.
(1) While there is still not much known about the pathophysiology of acute acalculous cholecystitis, it is generally thought of as a disease which effects patients with prolonged hospitalizations who are critically ill.
Neil, "Drainage of the gallbladder in patients with acute acalculous cholecystitis by transpapillary endoscopic cholecystotomy," Gastrointestinal Endoscopy, vol.
They suggested that invasion of the gallbladder caused an inflammatory adhesion which resulted in an acute acalculous cholecystitis [4].
Bedin, "Gallbladder melanoma mimicking acute acalculous cholecystitis.," Surgical Endoscopy, vol.
Acute acalculous cholecystitis associated with gallbladder perforation is often seen with severe infections like pneumonia, viral infections, and with enteric fever where the causative organism Salmonella typhii was identified in bile and are further concentrated in gallbladder (7).
There was one case (0.3%) each of acute acalculous cholecystitis and mucocele gallbladder.