ACVR1B(redirected from activin A receptor, type IB)
ACVR1BA gene on chromosome 12q13 that encodes activin receptor type IB, a receptor that forms a complex with other type-I and two type-II transmembrane serine/threonine kinase receptors for activin, a dimeric growth and differentiating factor belonging to the TGF-beta superfamily of structurally related signalling proteins. Type-II receptors phosphorylate and activate type-I receptors, which autophosphorylate, then bind and activate SMAD transcriptional regulators, playing roles in cell differentiation, growth arrest and apoptosis.
ACVR1B mutations are associated with pituitary tumours.
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