active site


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ac·tive site

that portion of an enzyme molecule at which the actual reaction proceeds; considered to consist of one or more residues or atoms in a spatial arrangement that permits interaction with the substrate to effect its reaction.

active site

n.
The part of an enzyme at which catalysis of the substrate occurs.

Active Site

The site in an enzyme where a substrate binds and an enzymatic reaction—e.g., ligation, oxidoreduction, etc.—occurs. The structure of the amino acid residues within the active site enhances substrate binding, substrate activation, and formation of a transition state.

ac·tive site

(ak'tiv sīt)
That portion of an enzyme molecule at which the actual reaction proceeds; one or more residues or atoms in a spatial arrangement that permits interaction with the substrate.

active site

1. The region of an ENZYME to which the substance being affected binds so as to undergo a catalyzed reaction.
2. The localized part of a protein to which a substrate binds.
Active siteclick for a larger image
Fig. 11 Active site . Lock-and-key mechanism of enzyme activity.

active site

an area of ENZYME surface which has a shape complementary to a particular SUBSTRATE, enabling the enzyme and substrate to become temporarily bonded to form an enzyme-substrate complex. Such a lock-and-key mechanism explains the great specificity of enzymes for substrates and also why changes in enzyme three-dimensional shape (by pH, temperature) cause alterations to enzyme activity.

Patient discussion about active site

Q. Are there any nice activities for adults with autism? I've been helping a very nice man of 45 of years old and I'm looking for some new things I can do with him in our time together. any ideas?

A. Autistic people react wonderfully with animals. for instance- i saw a group of severe Autistic teenagers going to swim with dolphins. the effect was amazing! taking him to the zoo, or even to the park to feed ducks, pet dogs, whatever.. could have a great effect on him.
hope i helped!
tell me how it went.

Q. what is a passive smoking? and is it dangerous as an active?

A. Passive smoking is the exposure to cigarettes smoke emitted from cigarettes smoke by other person. It's dangerous and may increase the risk to several diseases similar to active smoking (one's exposure to smoke emitted from the cigarettes he or she is smoking) although the risk is of lower magnitude. Example for passive smoking is children of smokers etc.

You may read more here:http://www.nlm.nih.gov/medlineplus/secondhandsmoke.html

Q. i swim a lot ! what are the advantages of swimming over other sport activities? on what part of the body does it work the most ?

A. its a good workout but your not really going to burn as much calories as a regular work out.

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References in periodicals archive ?
Meanwhile, the hydrogen production rate on local active sites will be obtained and analyzed.
Another possible explanation is related to sensitivity of the distinct active sites to the increase of DEAC concentrations.
1B illustrates the prepared structures of the protein after removal of hetero atoms, ligands and water molecules with a sphere around the active site.
Active Site. In the structure of the apo form, putative isocitrate-binding residues (Ser109, Asn111, Arg115, Arg125, Arg149, Asp298, Tyr156, Lys223', Asn225', and Arg274', the prime designates a residue from the adjacent subunit) involved in the binding of isocitrate in prokaryotic NADPIDHs are exposed to the inner surface in the deep cleft of the active site (Figure 3).
The [zeta] CA active site resembles that of [beta] Cas coordinating the metal ion to a His and two Cys residues (x, x+52, x+62, where x=263 in CDCA1) [45].
Recently, more than 200 ns MD simulations were performed to investigate the role of water molecules in the active site of CYP1A2 complexed with 7-ethoxyresorufin and ANF [87].
Afterwards, receptor grids were generated before docking with the active site determined by the position of cocrystal ligand.
The structural information of active site can be realized by the crystal structure of ligand-protein complex.
We created a simple and effective bioinformatics module to test its efficacy in educating students about phylogeny as well as visualizing and locating the active site of the subject enzymes in an undergraduate one-semester biochemistry class.
For the 3-phytase A, the active site is conformed by amino acids [R.sub.58], [H.sub.59], [R.sub.62], [R.sub.142], and [D.sub.339] [22] (Figure 3(b)), and for the 3-phytase B the active site is conformed by amino acids [R.sub.62], [H.sub.63], [R.sub.66], [R.sub.156], [H.sub.318], and [D.sub.319] [21] (Figures 3(c) and 3(d)).
Applications are open to athletes, who live in a district or borough with an Everyone Active centre or who are already a member of an Everyone Active site.
The Defence Ministry said that the Al-Raqqa raids last night targeted ISIL infrastructure and "an active site occupied by terrorist combatants." The French planes also hit an ISIL command centre, a stock of vehicles and maintenance workshops.

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