active metabolite

Active Metabolite

A drug metabolite with therapeutic activity similar to that of its parent compound, which must be considered in evaluating therapeutic pharmacokinetics.

active metabolite

Therapeutics A drug metabolite with therapeutic activity similar to the parent compound, which must be considered in therapeutic pharmacokinetics
References in periodicals archive ?
BHV-5000 was previously advanced into a Phase 1 clinical trial, as a drug in solution formulation, and the active metabolite of BHV-5000, lanicemine, was previously advanced through Phase 2 trials.
Leucovorin (LCV) acts as an essential coenzyme for nucleic acid synthesis and also it is an active metabolite of folic acid.
While the clinical profile of EPI-506 or its active metabolite, EPI-002, could potentially be enhanced through reformulation efforts, ESSA believes that prioritizing development of one of its next-generation NTD inhibitors (Aniten) with greater potency and other enhanced pharmaceutical properties offers the most compelling regulatory and commercial pathway.
The prodrug design and selection pathways are intended to address limitations of the active metabolite of a drug.
Clopidogrel is a prodrug that requires biotransformation by several hepatic cytochrome P-450 (CYP) isoenzymes including CYP2C19 to become an active metabolite [3].
Both linaclotide and its active metabolite bind to the guanylate cyclase-C receptor, on the luminal surface of the intestinal epithelium.
Modufolin is the key active metabolite of all clinically used folate-based drugs used today including Leucovorin and Levoleucovorin.
Twelve hours after the first dose was administered, mean (SD) concentrations of tramadol and its only active metabolite M1 (Odesmethyltramadol) were 53 [+ or -] 57 ng/mL and 6 [+ or -] 6 ng/mL, respectively.
A later forensic report also showed NA's urine sample contained both cocaine and benzyolecgonine, an active metabolite in cocaine.
The Desyne Nx stent is designed to treat heart vessel blockages by eluting a low dose of Elixir's proprietary drug Novolimus, an active metabolite of sirolimus (an immunosuppressant), via an ultra-thin durable coating.
Teriflunomide is the active metabolite of leflunomide, a synthetic, low-molecular-weight drug that was approved by the FDA in 1998 for the treatment of rheumatoid arthritis.
In the journal BMC Medicine, researchers from Texas Tech University Health Sciences report the discovery of a mechanism for diindolylmethane (DIM), an active metabolite of indole-3-carbinol found in cruciferous vegetables, to induce programmed cell death (apoptosis) in cultured ovarian cancer cells.