active metabolite

Active Metabolite

A drug metabolite with therapeutic activity similar to that of its parent compound, which must be considered in evaluating therapeutic pharmacokinetics.

active metabolite

Therapeutics A drug metabolite with therapeutic activity similar to the parent compound, which must be considered in therapeutic pharmacokinetics
References in periodicals archive ?
The principal active metabolite of venlafaxine, O-desmethylvenlafaxine {ODVI}, has a pharmacologic profile similar to that of its parent compound.
Employing a population pharmacokinetic model based on steady state exposure to DCC-2618 and the active metabolite, DP-5439, increasing doses of DCC-2618 resulted in dose proportional increases in the combined exposure.
The prodrug design and selection pathways pursued by Biohaven are intended to address limitations of the active metabolite of a drug.
The product is an active metabolite of tamoxifen and an FDA approved drug for breast cancer and breast cancer prevention in high risk women.
The active metabolite NCLD peaked at 0.5 hours, with a single-dose [C.sub.max] of 0.31 [micro]g/mL and a multidose [C.sub.max] of 0.64 [micro]g/mL.
"Finasteride blocks the conversion of testosterone to dihydrotestosterone, the active metabolite of testosterone, slowing the progression of androgenic alopecia and decreasing the incidence of prostate cancer," they wrote.
Vitamin D is a membrane antioxidant: thus Vitamin D3 (cholecalciferol) and its active metabolite 1,25-dihydroxycholecalciferol and also Vitamin D2 (ergocalciferol) and 7-dehydrocholesterol (pro-Vitamin D3) all inhibited iron-dependent liposomal lipid peroxidation.
This fact is of utmost clinical importance because N-desmethyltamoxifen is subject to hydroxylation, predominantly at the para position, to produce the major clinically active metabolite endoxifen.
Desvenlafaxine is the active metabolite of venlafaxine known popularly as Effexor.
Paliperidone, the principal active metabolite of risperidone (Risperdal), was evaluated in 6-week trials that included 1,665 patients from centers in North America, Europe, and Asia.
This single-rod, nonbiodegradable implantable contraceptive rod is 4 cm in length, 2 mm in diameter, and contains progestin etonogestrel, an active metabolite of desogestrel.
(Marlborough, MA; 508-481-6700) announced a licensing agreement with Janssen Pharmaceutica, NV, a wholly owned subsidiary of Johnson & Johnson Company (New Brunswick, NJ; 908-524-0400)(1997 revenue - $22.5 billion), relating to (+) norcisapride, an isomer of the active metabolite of Propulsid (cisapride).