activation-induced cytidine deaminase


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activation-induced cytidine deaminase (AID),

an enzyme implicated in the processes of somatic hypermutation and isotope class switch, in the generation of high-affinity antibodies.
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Activation-induced cytidine deaminase shows staining in the centroblasts of the germinal center, with scattered large cells in the paracortex (Figure 6, C).
Activation-induced cytidine deaminase is necessary for somatic hypermutation and class switch recombination.
SHM is a controlled process of introducing variability into the binding region of an antibody gene sequence and is catalyzed by the B-cell specific enzyme, Activation-Induced Cytidine Deaminase (AID).

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