activated thrombin

activated thrombin

A clot-promoting enzyme which converts fibrinogen to fibrin and protects against fibrinolysis by activating thrombin-activatable fibrinolysis inhibitor.

activated thrombin

Hematology A key clot promoting enzyme that converts fibrinogen to fibrin and protects against fibrinolysis by activating thrombin-activatable fibrinolysis inhibitor. See Fibrin, Fibrinolysis, TAFI.
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FXIII is transformed to activated FXIII by thrombin with the help of Ca[sup]2+ and catalyzes cross-linking of fibrin, converted from fibrinogen by activated thrombin [Figure 1].
-- The Thrombin Processing Device is a sterile blood processing disposable that prepares activated thrombin from a small aliquot of plasma in less than 30 minutes.
The intrinsic threshold of the fibrinolytic system is modulated by basic carboxypeptidases, but the magnitude of the antifibrinolytic effect of activated thrombin activable fibrinolyis inhibitor is masked by its instability.