activated protein C

Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia.
Related to activated protein C: Activated protein C resistance

Activated Protein C

A serine protease encoded by PROC, located on chromosome 2q14.3, which has a central role in coagulation, inflammation, apoptosis and in maintaining vascular permeability. Some data suggest that it may be of some use in managing sepsis.

activated protein C



An inhibitor of thrombin, and a fibrinolytic and anti-inflammatory agent produced in the bloodstream during sepsis.
References in periodicals archive ?
Factor V Arg 306 [right arrow] Gly mutation is not associated with activated protein C resistance and is rare in Taiwanese Chinese.
Extensive venous and arterial thrombosis associated with an inhibitor to activated protein C.
Lack of activated protein C resistance in healthy Hong Kong Chinese blood donors: correlation with absence of Arg506-Gln mutation of factor V gene [letter].
Activated protein C resistance assay performance: improvement by sample dilution with factor V--deficient plasma.
Resistance to activated protein C, the Arg506 to Gln mutation in the factor V gene, and venous thrombosis: functional tests and DNA-based assays, pros and cons.
Influence of storage conditions on activated protein C resistance assay [letter].
A new dilution for the modified APTT-based assay for activated protein C resistance: improvement of the reliability in patients with a lupus anticoagulant.
False positive activated protein C resistance test due to anti-phospholipid antibodies is corrected by platelet extract.
Full browser ?