activated partial thromboplastin time


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Related to activated partial thromboplastin time: Thrombin time, Prothrombin time, International normalized ratio

time

 [tīm]
a measure of duration. See under adjectives for specific times, such as bleeding time.
activated partial thromboplastin time (APTT, aPTT) the period required for clot formation in recalcified blood plasma after contact activation and the addition of platelet substitutes such as brain cephalins or similar phospholipids; used to assess the coagulation pathways. A prolonged aPTT can indicate a deficiency of any of various coagulation factors, including factors XII, XI, IX, VIII, X, V, and II, and fibrinogen.
AEC minimal response time the shortest duration at which x-ray exposure can be terminated by automatic exposure control.
atrioventricular sequential time a fixed nonprogrammable interval that extends from the atrial stimulus to the ventricular stimulus.
bleeding time the time required for a standardized wound to stop bleeding; used as a test for platelet disorders; see also bleeding time.
circulation time the time required for blood to flow between two given points; see also circulation time.
clotting time (coagulation time) the time required for blood to clot in a glass tube; see also clotting.
cold ischemia time the time between the placement of a traumatically amputated body part in ice and the time of surgical replantation.
inertia time the time required to overcome the inertia of a muscle after reception of a stimulus.
ischemia time the total time between traumatic amputation of a limb or portion of a limb and its surgical reimplantation; it is the sum of warm and cold ischemia times.
minimal response time in radiology, the shortest possible exposure time for an x-ray film to be exposed automatically.
one-stage prothrombin time prothrombin time.
prothrombin time see prothrombin time.
real time a term used to describe a recording device that shows events simultaneously to their occurrence.
thrombin time the time required for plasma fibrinogen to form thrombin; see also thrombin time.
warm ischemia time the time interval between traumatic amputation of a limb or part and its placement on ice.

ac·ti·vat·ed par·tial throm·bo·plas·tin time (aPTT),

the time needed for plasma to form a fibrin clot after the addition of calcium and a phospholipid reagent; used to evaluate the intrinsic clotting system.

activated partial thromboplastin time (APTT)

activated partial thromboplastin time

A test that evaluates the clotting factors of the intrinsic pathway—except VII and XIII—by measuring the time required to form a fibrin clot. aPTT is used to screen for bleeding tendencies and to monitor heparin therapy; it is increased in coagulation factor deficiencies (factors V, VIII, IX, X, XI, XII), DIC, Hodgkin lymphoma, hypofibrinogenemia, leukaemia, cirrhosis, vitamin K deficiency, von Willebrand’s disease, and in drug therapy—e.g., heparin and aspirin.
 
Ref range
30–40 seconds.

activated partial thromboplastin time

aPTT Hematology A test that evaluates the clotting factors of the intrinsic pathway–except VII and XIII, by measuring the time required to form a fibrin clot; aPTT is used to screen for bleeding tendencies and to monitor heparin therapy; it is ↑ in coagulation factor deficiencies–factors V, VIII, IX, X, XI, XII, DIC, Hodgkin's disease, hypofibrinogenemia, leukemia, cirrhosis, vitamin K deficiency, von Willebrand's disease, and in drug therapy–eg, heparin and aspirin Ref range 30-40 secs. See Prothrombin time.

ac·ti·vat·ed par·tial throm·bo·plas·tin time

(aPTT) (ak'ti-vā-tĕd pahr'shăl throm-bō-plas'tin tīm)
The time needed for plasma to form a fibrin clot following the addition of calcium and a phospholipid reagent; used to evaluate the intrinsic clotting system.

activated partial thromboplastin time

A measurement of the time taken for the clotting system of the blood to produce the clot protein known as fibrin. The time is generally 25 to 39 seconds. This measurement is a general test of the system and is also used to assess the effectiveness of the anticoagulant drug HEPARIN. It may also be used as the basis of a test for ACTIVATED PROTEIN C RESISTANCE.

Activated partial thromboplastin time

Partial thromboplastin time test that uses activators to shorten the clotting time, making it more useful for heparin monitoring.

thromboplastin

a substance in blood and tissues which, in the presence of ionized calcium, aids in the conversion of prothrombin to thrombin. Extrinsic and intrinsic thromboplastin are formed as the result of the interaction of different clotting factors; the factors that combine to form extrinsic thromboplastin are not all derived from intravascular sources, whereas those that form intrinsic thromboplastin are.

activated partial thromboplastin time
see activated partial thromboplastin time.
extrinsic thromboplastin
the prothrombin activator formed as a result of interaction of coagulation factors III, VII, and X which, with factor IV, aids in the formation of thrombin.
thromboplastin generation time (TGT)
evaluates the first stage in blood coagulation by measuring the efficiency of prothrombinase formation.
intrinsic thromboplastin
the prothrombin activator formed as a result of interaction of coagulation factors V, VII, IX, X, XI and XII and platelet factor 3 (PF-3), which, with factor IV, aids in the conversion of prothrombin to thrombin.
plasma thromboplastin antecedent (PTA)
clotting factor XI; deficiency occurs in cattle and dogs, causing mild to severe bleeding tendencies called hemophilia C.
plasma thromboplastin component (PTC)
clotting factor IX; deficiency causes christmas disease. Called also Christmas factor, antihemophilic factor B, autoprothrombin II.
thromboplastin time
see activated partial thromboplastin time.
tissue thromboplastin
factor III, a material derived from several sources in the body (e.g. brain, lung), and is important in the formation of extrinsic prothrombin converting principle in the extrinsic pathway of blood coagulation. Called also tissue factor.
References in periodicals archive ?
Prothrombin Time and Activated Partial Thromboplastin Time among type 2 non-insulin dependent Diabetes Mellitus.
The prothrombin time (PT) value was normal, and activated partial thromboplastin time (APTT) maintained to 2–3 folds prolonged due to 15 U*kg [sup]−1*h [sup]−1 of heparin sodium bumped intravenously followed by a loading dose of 25 U/kg i.
Activated partial thromboplastin time (APTT) is usually shortened in pregnancy, by up to 4 s in the third trimester, largely due to the hormonally influenced increase in factor VIII.
Serum calcium, phosphate, blood urea nitrogen (BUN), creatinine, parathyroid hormone levels, coagulation factors profile, prothrombin time, activated partial thromboplastin time, protein C and S assay, erythrocyte sedimentation rate (ESR), c-reactive protein (CRP), amylase and lipase can help establish a presumed cause.
5 s), typical activated partial thromboplastin time (aPTT) (31.
2 [micro]mol/L (normal reference: <12), antithrombin III activity 109% (normal range: 70-125%), prothrombin time 14 second (normal range: 10-14), and activated partial thromboplastin time 35second (normal range: 25-36).
2,3) In order to prevent activation of the hemostatic system into the circuit, unfractionated heparin (UH) is usually administered for patients on ECMO and therapeutic anticoagulation is monitored by various laboratory tests: activated clotting time, activated partial thromboplastin time (aPTT), anti-Xa assay, and thromboelastography.
Prothrombin time (PT) and activated partial thromboplastin time (APTT) remained within normal range during these days, except for transiently prolonged APTT on day 10 secondary to heparin.
The other data collected included demographic factors, diagnosis, Acute Physiology and Chronic Health Evaluation II score, Sequential Organ Failure Assessment score on the day of TEG testing (9), C-reactive protein concentration (10), fibrinogen concentration, International Normalised Ratio, activated partial thromboplastin time, active infection requiring antibiotics, thrombotic complications (deep vein thrombosis, pulmonary embolism, thrombotic stroke) and hospital mortality.
1) The most common way to monitor argatroban is using the activated partial thromboplastin time (aPTT) test, which is also recommended by the manufacturer for patients receiving prophylaxis or treatment for HIT.
ABBREVIATIONS: PT--prothrombin time, aPTT activated partial thromboplastin time, INR--international normalized ratio.

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