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a mature macrophage, in an active metabolic state, that is cytotoxic to tumor/target cells, usually following exposure to certain cytokines.
Synonym(s): armed macrophage
Farlex Partner Medical Dictionary © Farlex 2012
activated macrophageA mononuclear phagocyte that has been “turned on”—i.e., has enhanced activity by cytokines. Activated macrophages (AMs) are twice the size of resting macrophages and more aggressive (increased lysozymes and surface expression of MHC class-II antigens), and are pivotal in defending a host against microorganisms that grow well within histiocytes/tissue-based macrophages and other cells—e.g., Listeria spp, and Salmonella spp.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
activated macrophageImmunology A mononuclear phagocyte that has been 'turned on'–ie has enhanced activity by cytokines; AMs are bigger–twice the size of resting macrophages and 'badder'–↑ lysozymes and surface expression of MHC class II antigens, and are pivotal in defending against microorganisms that grow well in histiocytes/tissue-based macrophages and other cells–eg, Listeria spp, and Salmonella spp
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.