actinomycin D


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dac·ti·no·my·cin

(dak'ti-nō-mī'sin),
An antineoplastic antibiotic produced by several species of Streptomyces (for example, S. parvulus).
See also: actinomycins.
Synonym(s): actinomycin D
Farlex Partner Medical Dictionary © Farlex 2012

actinomycin D

The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

Actinomycin D

A relatively toxic antibiotic produced by Streptomyces spp, which is used as a chemotherapeutic.
Mechanism Inhibits DNA transcription by RNA polymerase.
Indications Rhabdomyosarcoma, Wilms’ tumour, gestational trophoblastic tumour 
Adverse effects Anorexia, nausea, vomiting, myelosuppression with pancytopenia, diarrhoea
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

actinomycin D

Cosmegen®, dactinomycin Oncology A relatively toxic antibiotic produced by Streptomyces spp, used as a chemotherapeutic Mechanism Inhibits DNA transcription by RNA polymerase Indications Rhabdomyosarcoma, Wilms' tumor Adverse effects Anorexia, N&V, myelosuppression with pancytopenia, diarrhea
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

actinomycin D

Dactinomycin, an antibiotic derived from Streptomyces pavullus which causes breaks in DNA. This side effect renders it unsuitable as an antibacterial drug, but makes it useful as an anti-cancer drug. A brand name is Cosmegen Lyovac. There are other actinomycins in the group produced by Streptomyces chrysomallas .
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

actinomycin D

a substance that inhibits the transcription of RNA from DNA. When isolated from soil bacteria and used pharmaceutically it acts as an ANTIBIOTIC.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005