actin binding proteins

actin binding proteins

A large collection of different proteins that function by binding to actin as part of the cytoskeleton. They include EF1 in pseudopodia; fascin in stress fibres, microvilli, and acrosomal process; scruin in acrosomal process; villin in microvilli; dematin in the red cell cortical network just under the plasma membrane; fimbrin in microvilli and adhesion plaques; spectrin in cortical networks; dystrophin in muscle cell cortical networks; and filamin in pseudopodia, stress fibres and filopodia.
References in periodicals archive ?
Clearly, the structural links between actin filaments and integrins are regulated in at least some cell types, and it would not be unreasonable to hypothesize that agents known to alter cell behavior may do so by affecting the expression or function of actin binding proteins such as vinculin, talin, paxillin and integrins that are recruited to focal adhesions (Mwakikunga et al., 2011).
Actin binding protein expression is altered in uterine luminal epithelium by clomiphene citrate, a synthetic estrogen receptor modulator.
In motile cells, actin dynamics are activated by extracellular stimuli, which in turn trigger intracellular signaling, including Rhofamily small GTPases, focal adhesion kinases, cofilin, LIM kinases, capping proteins, polymerization complexes, and other actin binding proteins (ABPs) [18, 19].
Talking specifically about the actin cytoskeleton function is worth to say that this is regulated by a plethora of actin binding proteins and specific signaling pathways.
Eukaryotes employ additionally more than 100 actin binding proteins (ABPs), generally falling in two classes with either actin monomer or filament binding properties.
54),55) These conformational changes are mediated along the actin filament, especially in the presence of the actin binding proteins tropomyosin and troponin.
Increased glucose levels are known to stimulate a variety of responses within GMC including remodeling of cytoskeletal elements like actin and actin binding proteins [24].
Actin-based movements and remodeling are sensitive to [Ca.sup.2+] changes which are affecting a plethora of actin binding proteins. Fine astrocytic processes contain mostly actin cytoskeleton, and the actin-binding protein alpha-actinin aggregates at the tip of growing filopodia in cultured astrocytes [22].