Bateman, "Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis," Journal of Molecular Medicine, vol.
Gerton, "Acrosome biogenesis begins during meiosis: evidence from the synthesis and distribution of an acrosomal glycoprotein, acrogranin, during guinea pig spermatogenesis," Biology of Reproduction, vol.
It is worth to mention the presence of an additional ligand capable of incorporating both TNF-R1 and TNF-R2 with still increasing importance in the pathogenesis of OA, which is progranulin (PGRN) also known as granulin epithelin precursor (GEP), PC-cell derived growth factor (PCDGF), proepithelin (PEPI), or acrogranin
In addition, granulin-epithelin precursor (GEP, a newly identified chondrogenic growth factor, which was also known as proepithelin, acrogranin
, progranulin (PGRN), and GP88/PC cell-derived growth factor) inhibited the action of ADAMTS-12 preventing COMP degradation via two distinct mechanisms [61, 92-97].
Progranulin, also known as granulin/epithelin precursor (GEP), acrogranin
, and PC cell-derived growth factor (PCDGF), is a 593 amino acid growth factor [1, 2].