acro-osteolysis

acro-osteolysis

(ak?ro-oos?te-ol'i-sis) [acro- + osteolysis]
1. A familial disease causing dissolution of the tips of the bones in the extremities of young children. There is no history of trauma, and spontaneous amputation does not occur. Its cause is unknown.
2. An occupational disease seen in workers who come in contact with vinyl chloride polymerization processes. It is marked by Raynaud's phenomenon, scleroderma-like skin changes, and radiological evidence of bone destruction of the distal phalanges of the hands. Recovery follows removal from exposure. See: Raynaud's disease
References in periodicals archive ?
The phenotypic findings in HCS that particularly relate to abnormal bone turnover are acro-osteolysis and wormian bones in the skull sutures.
Acro-osteolysis. Eur J Rheumatol 2019; 6(2): 109-10.
Abnormality in X-ray hands was found in 18 (33.3%) cases, of which 8 (14.8%) cases showed acro-osteolysis, 5 (9.3%) cases showed contracture and another 5 (9.3%) cases showed both these features.
A syndrome of keratosis palmo-plantaris congenita, pes planus, onychogryphosis, periodontosis, arachnodactyly and a peculiar acro-osteolysis. Br J Dermatol 1986; 115: 243-48.
Films of the hands showed aplastic terminal phalanges in keeping with acro-osteolysis.
Primary HOA or pachydermoperiostosis is a rare hereditary disorder characterized by digital clubbing, subperiosteal new bone formation, acro-osteolysis, hypertrophy of soft tissues and glands, particularly in the face and scalp resulting in wrinkling of skin.
Acro-osteolysis: a complication of Jadassohn-Lewandowsky syndrome.
Bone resorption (osteopaenia) * Sub-periosteal Radial aspect of middle phalanges, medial side of humerus, tibia * Intracortical Terminal tufts(acro-osteolysis) * Endosteal Hands and long bones * Trabecular Skull (salt and pepper appearance) * Sub-ligamentous Trochanters, calcaneus, ischial/humeral tuberosities, lateral clavicle * Sub-chondral Acromioclavicular, sacro-iliac and sternoclavicular joints 2.
in 1991 proposed diagnostic criteria for PDP i) major criteria: digital clubbing, periostosis, and pachydermia and ii) minor criteria: seborrhea, hyperhidrosis, folliculitis, arthritis or arthralgia, gastritis or gastric ulcer, acro-osteolysis, neurovegetative syndrome, hypertrophic gastropathy and cutis verticis gyrate.
(4) Radiologically, acro-osteolysis, periosteal changes of short, long and flat bones, and ossification of ligaments and interosseous membranes have been reported.
X ray AP views of both hands (c, d) showing short metacarpals, phalanges with distal tuft resorption (acro-osteolysis).
A patient with acro-osteolysis syndrome: Hajdu-Cheney.