Acridines | definition of acridines by Medical dictionary
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acridines dyes which can bind to NUCLEIC ACIDS and insert themselves between the adjacent BASES, a process called intercalation. Acridines can inhibit DNA and RNA synthesis and can cause FRAMESHIFT mutations. They are used as MUTAGENS, for example, proflavine (proflavin), as ANTIMICROBIALS, for example acriflavine (acriflavin), and as fluorescent stains for nucleic acids, for example acridine orange. They may also be used to eliminate PLASMIDS from CELLS of BACTERIA, a process known as curing.
References in periodicals archive
2, the main nitrogen compounds in the feedstock are nitriles, anilines, pyridines, quinolines, acridines
, indoles and carbazoles.
THE SYNTHESIS OF A NEW CLASS OF POSSIBLE ANTI-TUMOR DRUGS: 9-HYDROXYAMlNOMETHYLENE ACRIDINES
The antimutagenic effect of these substances was estimated against acridine
orange (AO)- and ofloxacin-induced damage of chloroplast DNA in Euglena gracilis assay.