acridine orange


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ac·ri·dine or·ange

(ak'ri-dēn ōr'enj), [C.I. 46005]
3,6-bis(dimethylamino)acridine hydrochloride; a basic fluorescent dye useful as a metachromatic stain for nucleic acids; also used in screening cervical smears for abnormal and malignant cells, where unusual amounts of DNA and RNA occur during proliferation and in tumors (DNA fluoresces yellow to green; RNA fluoresces orange to red).
An immunologic fluorochrome—fluorescent dye—that nonspecifically binds to RNA (red fluorescence), DNA (green fluorescence), proteins, polysaccharides, glycosaminoglycans
Toxicology AO is carcinogenic, causing mutations by intercalating itself within replicating DNA causing insertional or deletional (‘frame shift’) mutations; AO is not routinely used in histologic laboratories

ac·ri·dine or·ange

(ak'ri-dēn awr'ănj)
[CI 46005] A basic fluorescent dye useful as a metachromatic stain for nucleic acids; also used in screening cervical smears for abnormal and malignant cells.
References in periodicals archive ?
The effect of washing, frequency of washing, heating of tampon solution and concentration of acridine orange was compared using non parametric Mann-Whitney test.
The performance of a-Sb2O4 as photocatalyst was evaluated by degrading acridine orange and the extent of degradation was monitored by UV-vis.
Acridine orange staining for rapid diagnosis of acanthamoeba keratitis.
Acridine orange staining of catheter pieces exposed to biofilm forming bacterial strains [17]
an application of acridine orange fluorescent staining to the micronucleus test.
The fluorescence of the dye acridine orange (1) and its quenching in polymer matrices has been studied extensively [18-20].
Rapid nuclear staining of Rhizoctonia solani and related fungi with acridine orange and with safranin O.
High prevalence of Plasmodium malariae and Plasmodium ovale in malaria patients along the Thai-Myanmar border, as revealed by acridine orange staining and PCR based diagnoses.
A rapid sensititive, simple and economical method for detection of Anaplasma marginale by Fluorescent microscopy with acridine orange and ethid ium bromide.