Also found in: Acronyms, Encyclopedia, Wikipedia.
ac·ri·dine or·ange(ak'ri-dēn ōr'enj), [C.I. 46005]
3,6-bis(dimethylamino)acridine hydrochloride; a basic fluorescent dye useful as a metachromatic stain for nucleic acids; also used in screening cervical smears for abnormal and malignant cells, where unusual amounts of DNA and RNA occur during proliferation and in tumors (DNA fluoresces yellow to green; RNA fluoresces orange to red).
Synonym(s): tetramethyl acridine
Farlex Partner Medical Dictionary © Farlex 2012
Toxicology AO is carcinogenic, causing mutations by intercalating itself within replicating DNA causing insertional or deletional (‘frame shift’) mutations; AO is not routinely used in histologic laboratories
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
ac·ri·dine or·ange(ak'ri-dēn awr'ănj)
[CI 46005] A basic fluorescent dye useful as a metachromatic stain for nucleic acids; also used in screening cervical smears for abnormal and malignant cells.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012