Acral lentiginous melanoma (ALM) was the most common subtype in Blacks but was the least common subtype in NHW; API had a much higher proportion of ALM cases compared to NHW.
3-8,16) Historically, three main subtypes of melanoma including superficial spreading melanoma (SSM), lentigo maligna melanoma (LMM) and nodular melanoma (NM) were first described in 1969; (9) desmoplastic melanoma (DM) was added in 1971; (12) and acral lentiginous melanoma (ALM) was introduced in 197710 and defined in 1980.
3) In addition, a number of other negative prognostic factors are present, which translates into reduced survival; these include unfavourable subungual, plantar and mucosal primary sites and a disproportionate preponderance of acral lentiginous melanoma.
Measurement of c-myc oncogene expression provides an accurate prognostic marker for acral lentiginous melanoma.
An analysis of p16 tumour suppressor gene expresion in acral lentiginous melanoma.
Acral lentiginous melanoma mimicking benign disease: the Emory experience.
Acral lentiginous melanomas
develop on palmar, plantar and subungual skin and are, with few exceptions, the only form of melanoma occurring in black people.
In non-white populations, acral lentiginous melanoma constitutes 29% to 72% of all melanomas
Freedberg I, Acral lentiginous melanoma, In: Fitzpatrick's Dermatology in General Medicine.
Acral lentiginous melanoma
is easy to diagnose clinically in advanced stages; the flat, darkly pigmented lesion on the sole of a foot that is several centimeters in diameter can hardly be anything but a melanoma.
Four primary groups have been traditionally proposed based on a combination of clinical and pathologic features: superficial spreading melanoma, nodular melanoma, lentigo maligna melanoma and acral lentiginous melanoma
Differential expression of melanoma associated antigens in acral lentiginous melanoma
and in nodular melanoma lesions.