mal de Meleda

(redirected from acral keratoderma)

mal

 [mal] (Fr. and Sp.)
mal de Meleda symmetrical keratosis of the palms and soles associated with a dry, scaly thickening of the wrists and ankles.
mal de mer seasickness.

mal de Me·le·da

[MIM*248300]
endemic symmetrical keratoderma of the extremities occurring on the island of Meleda off the coast of Dalmatia, in Eastern Europe.

mal de Meleda

An autosomal recessive condition (OMIM:248300) causing symmetric palmoplantar hyperkeratosis and acanthosis, with circumscribed hyperkeratosis of wrists, knees, forearms, ankles, brachydactyly, koilonychia, growth and mental retardation, seen in the endogamous population of the island of Meleda off the coast of Dalmatia in former Yugoslavia.
 
Molecular pathology
Mal de Meleda is caused by a mutation of SLURP1 on chromosome 8q24.3.

Mal de Meleda

An autosomal recessive condition (OMIM:248300) causing symmetric palmoplantar hyperkeratosis and acanthosis, with circumscribed hyperkeratosis of wrists, knees, forearms, ankles, brachydactyly, koilonychia, growth and mental retardation, seen in the endogamous population of the island of Meleda off the coast of Dalmatia in former Yugoslavia.
 
Molecular pathology
Mal de Meleda is caused by a mutation of SLURP1 on chromosome 8q24.3.
References in periodicals archive ?
[6] Additional features in a Dutch family with woolly hair included dental caries, acral keratoderma and facial abnormalities.