Necrolytic acral erythema
(NAE) is a rare but distinct clinical entity.
3) TEC includes Burgdorf's Reaction, erythrodysesthesia, acral erythema
, toxic acral erythema
, eccrine squamous syringometaplasia, epidermal dysmaturation, epidermal dystrophy, hand-foot syndrome, palmar-plantar erythema, palmarplantar dysesthesia, and neutrophilic eccrine hidradenitis.
Chemotherapy Induced Acral Erythema
(Hand-Foot Syndrome) Global Clinical Trials Review, H1, 2014
46, 47) Necrolytic acral erythema
is almost exclusively seen in HCV infection.
Dermatologic toxicities include rash, acral erythema
, alopecia, pruritis, subungal splinter hemorrhages, hair depigmentation, skin discoloration, and xerosis.
3,4) It represents reversible palm and sole acral erythema
, accompanied by various degrees of dysesthesia and epidermal desquamation at the pressure points, and is seen in approximately 30% of patients taking sorafenib.
The taxanes are already known to be potential causes of a variety of other skin disorders, including alopecia, mucositis, acral erythema
, pseudoscleroderma, and nail changes.
These included generalized pruritus 30%, lichen planus 30%, urticaria 26%, leukocytoclastic vasculitis 25%, necrolytic acral erythema
20% and porphyria cutanea tarda 4%.
Mild cases of hand-foot syndrome consist of a painful acral erythema
In 2000, the first and only case of necrolytic acral erythema
associated with hepatitis C infection in the United States was reported (Arch.
Hand-foot syndrome (HFS) also called hand- foot skin reaction palmar-plantar erythrodysesthesia acral erythema
Burgdorf reaction is a dose limiting cutaneous toxicity of many chemotherapeutic agents.
Abstract Necrolytic acral erythema
(NAE) is a newly recognized dermatosis which has been regarded as early cutaneous marker of hepatitis C virus (HCV) infection.